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ProteomicsEffect of PTFGRN Expression on the Proteomic Profile of A431 Cells and Determination of the PTGFRN Interactome
The exact molecular mechanisms by which PTGFRN influences cancer progression are still unknown. Our laboratory set out to investigate how PTGFRN knockdown affected the expression of other proteins. We also carried out co-immunoprecipitation experiments using a monoclonal anti-PTGFRN antibody. We emp...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD048092 | Pride
A431 Ptgfrn Mass spectrometry Interactome Proteome Co-immunoprecipitate 
ProteomicsThe human innate immune protein calprotectin elicits a multi-metal starvation response in Pseudomonas aeruginosa
To combat infections, the mammalian host limits availability of essential transition metals such as iron (Fe), zinc (Zn), and manganese (Mn) in a strategy termed “nutritional immunity”. The innate immune protein calprotectin (CP) contributes to nutritional immunity by sequestering these metals to ex...
ORGANISM(S): Pseudomonas aeruginosa PA14 
2021-07-29 | PXD027638 | Pride
Innate immune Calprotectin Multi-metal starvation Pseudomonas aeruginosa 
ProteomicsThe heme-responsive PrrH sRNA regulates Pseudomonas aeruginosa pyochelin gene expression
Pseudomonas aeruginosa is an opportunistic pathogen that requires iron for growth and virulence, yet this nutrient is sequestered by the innate immune system during infection. When iron is limiting, P. aeruginosa expresses the PrrF1 and PrrF2 small regulatory RNAs (sRNAs), which post-transcriptional...
ORGANISM(S): Pseudomonas aeruginosa 
2023-08-11 | PXD040948 | Pride
Pseudomonas aeruginosa Heme-responsive Iron Prrf1 
ProteomicsDifferential patterns of protein expression in monolayer or spheroid melanoma cell models of acquired resistance to BRAF and MEK1/2 inhibitors
Mitogen activated protein kinase (MAPK) inhibitors are important therapies for treating many cancers. However, the development of acquired resistance to most protein kinase inhibitors limit their ability to provide durable responses. Approximately 50% of malignant melanomas contain activating mutati...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026952 | Pride
Monolayer Braf Drug resistance Protein kinases Kinase targeted therapy Selumetinib Spheroids Melanoma Vemurafenib Extracellular-signal regulated kinases 
ProteomicsRole of cellular retinol-binding protein, type 1 and retinoid homeostasis in the adult mouse heart: a multi-omic approach
The main active metabolite of Vitamin A, all-trans retinoic acid (RA), is responsible for proper cellular function and tissue organization. The role of RA has been extensively studied in development, but there is limited research on its role in the adult heart. Cellular retinol-binding protein, type...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-13 | PXD029349 | Pride
Heart Retinoid metabolism Mice Retinoic acid Cellular retinol binding protein type 1 
ProteomicsNew molecular insights into atrial fibrillation due to obscurin Ig58/59 deletion
Obscurins are giant, modular, cytoskeletal proteins that regulate striated muscle structure and function. Immunoglobulin domains 58/59 (Ig58/59) of obscurin interact with diverse proteins including titin variants and phospholamban. Mutations within Ig58/59 that alter these binding interactions have ...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-11 | PXD028904 | Pride
Arrhythmia Z-disk Ca2+ cycling Obscurin Atrial fibrillation 
ProteomicsSARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis
SARS-CoV-2 infection causes COVID-19, a severe acute respiratory disease associated with cardiovascular complications including long-term outcomes. The presence of virus in cardiac tissue of patients with COVID-19 suggests this is a direct, rather than secondary, effect of infection.Here, by express...
ORGANISM(S): Homo sapiens (Human) 
2022-10-04 | PXD036447 | Pride
Human hek 293t cell line 
ProteomicsThermal proteome profiling and proteome analysis using high-definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next-generation galeterone analog VNPP433-3β in castration-resistant prostate cancer
Cholesterol (CHOL) homeostasis is significantly modulated in prostate cancer (PCa) suggesting an active role in PCa development and progression. Several studies indicate a strong correlation between elevated CHOL levels and increased PCa risk and severity. Inhibition of CHOL biosynthesis at differen...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD060338 | Pride
Next generation galeterone analog Cyp51a1 Thermal proteome profiling Cholesterol Prostate cancer Lanosterol synthase 
ProteomicsNoncoding dsRNA induces Retinoic Acid synthesis to stimulate regeneration
We uncover a novel mechanism whereby developmental pathways are reactivated in adults to promote regeneration.
ORGANISM(S): Homo sapiens (Human) 
2019-05-23 | PXD013854 | Pride
Regeneration Retinoic acid Noncoding dsrna 
ProteomicsDisruption of Heme Uptake and PrrF sRNA Expression in the Pseudomonas aeruginosa PhuS H209A Variant Induces a Metabolic Stress-Response
The Pseudomonas aeruginosa heme-binding protein PhuS plays a central role in coordinating heme utilization with iron homeostasis through the PrrF small RNAs. Proteomic and metabolomic analyses of the phuSH209A allelic strain demonstrated that the previously characterized in vitro disruption of PhuS ...
ORGANISM(S): Pseudomonas aeruginosa PA103 
2026-09-28 | PXD079786 | Pride
Heme-binding protein Pseudomonas aeruginosa Prrf small rnas Phus H209a variant 
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