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ProteomicsSTAT3-dependent systems-level analysis reveals PDK4 to be associated with favorable outcome in primary prostate cancer.
Prostate cancer has a broad spectrum of clinical behavior, hence biomarkers are urgently needed for risk stratification. We previously described the protective effect of signal transducer and activator of transcription 3 (STAT3) in a prostate cancer mouse model. We now show the importance of STAT3-r...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-04-22 | PXD014251 | Pride
Tcga Metabolomics Pdk4 Oxphos Ffpe-proteomics Gene co-expression network analysis Stat3 Transcriptomics Prostate cancer Tca 
TranscriptomicsTranscription profiling of mouse embryonic day 13.5 and 15.5 fetal livers lacking p38alpha, a mitogen-activated kinase that controls inflammatory responses and cell proliferation
The mitogen-activated protein kinase (MAPK) p38alpha controls inflammatory responses and cell proliferation. Using mice carrying conditional p38alpha alleles, we investigated its function in postnatal development and tumorigenesis. When p38alpha is specifically deleted in the mouse embryo, fetuses d...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-7342 | biostudies-arrayexpress
UnknownBlocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T-cell lymphoma
Not available
S-SCDT-10_15252-EMMM_202115200 | biostudies-other
UnknownTargeting Pre-Existing Club-Like Cells in Prostate Cancer Potentiates Androgen Deprivation Therapy
Not available
S-SCDT-10_1038-S44321-026-00375-Y | biostudies-other
TranscriptomicsALK-dependent transcription factor networks are associated with epigenomic alterations of DNA methylation in ALCL
Aberrant DNA methylation patterns of malignant cells allow for the study of the tumor phenotype and behavior, and can be used for tumor classification. Here, we describe the genome-wide DNA methylation signatures of a T cell lymphoma that is driven by the oncogenic fusion protein NPM-ALK. Difference...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-66881 | biostudies-arrayexpress
TranscriptomicsNPMâ??ALK permits the survival of thymic T cells with aberrant T cell receptor rearrangements enabling thymic escape and tumor development
We present evidence to support a new model of Anaplastic Large Cell Lymphoma (ALCL) pathogenesis in which the malignancy is initiated in early thymocytes, prior to TCR rearrangement which is bypassed in NPMâ??ALK transgenic mice following Notch1 expression. In support, we show that T cell receptor (...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-67131 | biostudies-arrayexpress
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