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ProteomicsThe B Cell Repertoire in Multiple Sclerosis Reveals Molecular Mimicry between EBNA1 and GlialCAM
This data set contains the mass spectrometry raw files for the paper The B Cell Repertoire in Multiple Sclerosis Reveals Molecular Mimicry between EBNA1 and GlialCAM. In multiple sclerosis (MS) intrathecal B lymphocytes are directly involved in inflammation and secrete oligoclonal immunoglobulin. Ho...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-02-11 | MSV000086842 | MassIVE
ProteomicsParallel reaction monitoring assay development for multiple sclerosis biomarkers in cerebrospinal fluid.
We have developed and tested parallel reaction monitoring (PRM) assays for 25 proteins highly relevant as cerebrospinal fluid (CSF) biomarkers for multiple sclerosis, representing various biological processes affected in the disease. The proteins were represented by 72 peptides selected according to...
ORGANISM(S): Homo Sapiens Rattus Norvegicus 
2021-05-20 | PXD017281 | panorama
OtherSerum proteomic analysis of a pre-symptomatic multiple sclerosis cohort.
Data from Massive, ID: MSV000078865. File: JS_serum_pools_23_step03.mzml. Data published as part of Eur J Neurol. 2014 Aug 7 . From the Abstract: {{i}} This preliminary study utilized pre-symptomatic and post-symptomatic serum from a sample of 100 incident population-based US military veterans with...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310003985 | GPMDB
Resource Reanalysis 
ProteomicsTDP-43-stratified single-cell proteomic profiling of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis
Single cell dataset of human motor neurons laser-captured from postmortem ALS and control tissues (1) ALS Pilot dataset (2) TDP43 stratified dataset Summary: Unbiased proteomics has been employed to interrogate central nervous system (CNS) tissues (brain, spinal cord) and fluid matrices (CSF, plas...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-07 | MSV000092119 | MassIVE
ProteomicsHuman brain LC-MS/MS - Brain Citrullination Patterns and T Cell Reactivity of Cerebrospinal Fluid-Derived CD4+ T Cells in Multiple Sclerosis
Citrullination as a post-translational modification has been described in a couple of autoimmune diseases like rheumatoid arthritis (RA) and multiples sclerosis (MS). We investigated citrullination brain tissue from MS patients and healthy individuals (HD). The myelin sheath proteins have been the f...
ORGANISM(S): Homo sapiens (Human) 
2019-04-10 | PXD008344 | Pride
Pressure cycle technology (pct) Post-translational modification (mbp) Mass spectrometry Human post mortem brain tissue Hydrophilic interaction liquid chromatography hilic Myelin basic protein Citrullination Multiple sclerosis (ms) Neurodegeneration 
ProteomicsMS analysis of phosphopeptides enriched from the lumbar spinal cord of SOD1G93A mice at 20weeks.
This project is "Phosphoproteomic analysis of the lumbar spinal cord, a lesion site in the amyotrophic lateral sclerosis (ALS) mouse model SOD1G93A mice". The aim of this study is to clarify the phosphorylation changes by the lumbar spinal cord of SOD1G93A mice at 20w by applying proteomics technolo...
ORGANISM(S): Mus Musculus (mouse) 
2022-05-19 | PXD030651 | JPOST Repository
ProteomicsMultiple sclerosis biomarker discovery in cerebrospinal fluid using glycopeptide enrichment, TMT labeling and LC-MS/MS
Multiple sclerosis biomarker discovery in pooled cerebrospinal fluid (CSF) using glycopeptide enrichment, TMT labeling and LC-MS/MS. Comparing 3 pools of CSF from relapsing-remitting MS (RRMS) patients to 3 pools of CSF from patients with other neurological diseases (OND). To reveal protein groups a...
ORGANISM(S): Homo sapiens (Human) 
2016-10-13 | PXD004540 | Pride
Human Cerebrospinal fluid Tmt Discovery Glycopeptide enrichment Lc-ms/ms 
ProteomicsNeurodegeneration and humoral response proteins in cerebrospinal fluid associate with pediatric-onset multiple sclerosis -- Discovery
The pathogenesis of multiple sclerosis (MS) remains to be elucidated. Pediatric-onset MS (POMS) represents the earliest stage of the disease. CSF proteins in POMS may therefore provide causal information. Therefore, the aim of the current study was to analyze CSF proteins in children with an initial...
ORGANISM(S): Homo sapiens (Human) 
2022-09-30 | PXD031004 | Pride
Proteomics Proteins Mass spectrometry Cerebrospinal fluid Multiple sclerosis Pediatrics 
ProteomicsProteins co-localized with RNA Pol2 in ALS patient-derived neural precursors
Deficiency of proteostasis and RNA metabolism are increasingly recognized as critical drivers of neurodegenerative diseases. In this study, we focused on RNA polymerase II (Pol2) as the converging point of these two elements to understand how transcriptional machinery is affected by ALS-associated V...
ORGANISM(S): Homo Sapiens (human) 
2023-03-02 | PXD034483 | JPOST Repository
ProteomicsFoamy microglia link oxylipins to disease progression in multiple sclerosis
Multiple sclerosis (MS) is a neuroinflammatory disease characterized by expanding demyelinating lesions, leading to severe and irreversible disability.1–4 The mechanisms driving lesion expansion, however, remain poorly understood.5 Here, using a multi-omics approach, we identified foamy microglia le...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD056856 | Pride
Multiomics Human brain proteomics Ms Multiple sclerosis 
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