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ProteomicsLabel-free global proteome profiling of European American and African American bladder tumor patients.
Bladder cancer (BLCA) mortality is higher in African American (AA) patients compared to their European American (EA) counterparts, but the molecular mechanism underlying differences are unknown. . Thus, we performed proteomics analysis of AA and EA BLCA and identified higher mitochondrial OXPHOS spe...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-08 | MSV000095559 | MassIVE
ProteomicsDirect proteome labelling in fruit flies with SILAF reveals differential phosphorylation of mitochondrial proteins upon loss of OXPHOS subunits
Drosophila melanogaster has been a workhorse of genetics and cell biology for more than a century. However, proteomic-based methods have been limited due to the complexity and dynamic range of the fly proteome and the lack of efficient labelling methods. Here, we advanced a chemically defined food s...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-02-10 | PXD009990 | Pride
Holidic Fly Silaf Bsf Fruit fly Oxphos Lrpprc Silac Drosophila Methods development Drosophila melanogaster 
ProteomicsComplex II assembly drives metabolic adaptation to OXPHOS dysfunction
During acute oxidative phosphorylation (OXPHOS) dysfunction, the reverse activity of succinate dehydrogenase (Complex II) maintains the redox state of the Coenzyme Q pool by utilizing either fumarate or oxygen as terminal electron acceptors. The tendency for one over another has been suggested to be...
ORGANISM(S): Homo sapiens (Human) 
2025-06-06 | PXD064653 | Pride
Mitochondria Oxphos Sdh 
ProteomicsComplex II assembly drives metabolic adaptation to OXPHOS dysfunction
During acute oxidative phosphorylation (OXPHOS) dysfunction, the reverse activity of succinate dehydrogenase (Complex II) maintains the redox state of the Coenzyme Q pool by utilizing either fumarate or oxygen as terminal electron acceptors. The tendency for one over another has been suggested to be...
ORGANISM(S): Homo sapiens (Human) 
2025-06-06 | PXD064649 | Pride
Mitochondria Tca cycle Oxphos Sdh 
ProteomicsComplex II assembly drives metabolic adaptation to OXPHOS dysfunction
During acute oxidative phosphorylation (OXPHOS) dysfunction, the reverse activity of succinate dehydrogenase (Complex II) maintains the redox state of the Coenzyme Q pool by utilizing either fumarate or oxygen as terminal electron acceptors. The tendency for one over another has been suggested to be...
ORGANISM(S): Homo sapiens (Human) 
2025-06-06 | PXD064658 | Pride
Mitochondria Tca cycle Oxphos Sdh 
ProteomicsComplex II assembly drives metabolic adaptation to OXPHOS dysfunction.
During acute oxidative phosphorylation (OXPHOS) dysfunction, the reverse activity of succinate dehydrogenase (Complex II) maintains the redox state of the Coenzyme Q pool by utilizing either fumarate or oxygen as terminal electron acceptors. The tendency for one over another has been suggested to be...
ORGANISM(S): Homo sapiens (Human) 
2025-06-06 | PXD064675 | Pride
Mitochondria Tca cycle Oxphos Sdh 
ProteomicsDefective mitochondrial translation due to loss of COX14 function triggers ROS-induced inflammation in liver
Mitochondrial oxidative phosphorylation (OXPHOS) fuels cellular ATP demands. OXPHOS defects lead to severe human disorders with unexplained tissue specific pathologies. Mitochondrial gene expression is essential for OXPHOS biogenesis since core subunits of the complexes are mitochondrial-encoded. CO...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-25 | PXD041783 | Pride
Mouse Ros Liver Cox14 
ProteomicsMitochondrial proteome of human leuekmia.
Proteome characterization of isolated mitochondria samples prepared from three commonly used acute leukemia cell lines (HL-60, KG-1, MV-4-11). Data were compared to isolated mitochondria prepared from peripheral blood mononuclear cells (PBMC), isolated from healthy human subjects.
ORGANISM(S): Homo Sapiens (human) 
2020-08-04 | PXD020715 | JPOST Repository
ProteomicsThe mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in maintaining mitochondrial metabolic homeostasis
The molecular chaperone TRAP1, the mitochondrial isoform of cytosolic HSP90, remains poorly understood with respect to its pivotal role in the regulation of mitochondrial metabolism. Most studies have found it to be an inhibitor of mitochondrial oxidative phosphorylation (OXPHOS) and an inducer of t...
ORGANISM(S): Homo sapiens (Human) 
2020-01-16 | PXD015789 | Pride
Oxidative phosphorylation Hsp90 Atp synthase Trap1 Molecular chaperone Mitochondria Glutamine Proteomics 
ProteomicsAn updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease - Quantitative patient LCL proteomics
arise from defects in oxidative phosphorylation (OXPHOS). Their complex mode of inheritance and diverse clinical presentations render the diagnosis of MDs challenging and, to date, most lack a cure. Here, we build on previous efforts to discover genes necessary for OXPHOS and report a highly complem...
ORGANISM(S): Homo sapiens (Human) 
2025-07-30 | PXD060152 | Pride
Mitochondria Oxphos Intermembrane space Mitochondrial disease Respiratory chain 
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