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TranscriptomicsJeB001: Elucidation of the distal convoluted tubule transcriptome identified new candidate players in magnesium balance
The distal convoluted tubule (DCT) plays a key role in the fine-tuning of renal Mg2+ reabsorption. In recent years, hereditary magnesium (Mg2+) transport disorders have helped to identify important players in DCT Mg2+ homeostasis. Here, we report the Mg2+-sensitive transcriptional expression of the ...
ORGANISM(S): Mus musculus 
2013-12-13 | E-GEOD-40208 | biostudies-arrayexpress
ProteomicsSUMOylation proteomic analysis of renal distal convoluted tubule cells
We profiled SUMO1 and SUMO2 modified proteins in distal convoluted tubule (mpkDCT) as a precursor to targeted approaches to assess SUMO function. SUMO levels in cells following heat shock and treatment with deSUMOylation inhibitors were assessed.
ORGANISM(S): Mus musculus (Mouse) 
2021-11-25 | PXD028507 | Pride
Distal convoluted tubule Renal Kidney Sumoylation 
ProteomicsQuantitative Phosphoproteomic Identification of Novel Vasopressin-mediated Signaling Networks in Kidney Distal Convoluted Tubule Cells
The kidney distal convoluted tubule (DCT) plays an important role in body sodium regulation and thus control of blood pressure. The main sodium reabsorption pathways in the DCT are the epithelial sodium channel (ENaC) and the thiazide-sensitive NaCl cotransporter (NCC), the functions of which can be...
ORGANISM(S): Mus musculus (Mouse) 
2015-08-04 | PXD001729 | Pride
Phosphoproteomics Vasopressin Signaling networks Quantitation Kidney distal convoluted tubule cells 
ProteomicsComparative proteomic analysis of kidney distal convoluted tubule and cortical collecting duct cells following long-term hormonal stimulation
The distal convoluted tubule (DCT) and the cortical collecting ducts (CCD) are portions of renal tubule that are partly responsible for maintaining the systemic concentrations of potassium, sodium, calcium and magnesium. Despite being structurally similar, DCT and CCD cells have different transport ...
ORGANISM(S): Mus musculus (Mouse) 
2017-12-15 | PXD005454 | Pride
Distal convoluted tubule Mouse Hormone Kidney Cortical collecting duct Long-term 
TranscriptomicsIdentification of renal distal convoluted tubules enriched genes
The renal distal convoluted tubule DCT is a short part of the distal nephron with specific functions transporting ions and thereby modifying Na, Ca, Mg, K balance A transcriptomic analysis of the DCT was performed to identify specific gene expression which would implicate those genes in specific DCT...
ORGANISM(S): Mus musculus 
2013-11-19 | E-GEOD-51935 | biostudies-arrayexpress
TranscriptomicsRNA-seq profiling of microdissected rat renal tubule segments
We sequenced mRNAs from glomeruli and 14 different rat renal tubule segments collected by hand microdissection. Collagenase-digested rat renal tubule segments were collected by hand microdissection. Poly(A)-mRNAs were captured from cell lysate and sequenced using paired-end protocol.
ORGANISM(S): Rattus norvegicus 
2015-03-31 | E-GEOD-56743 | biostudies-arrayexpress
GenomicsEnriched Single-Nucleus RNA-Sequencing Reveals Unique Attributes of Distal Convoluted Tubule Cells
Enriched Single-Nucleus RNA-Sequencing Reveals Unique Attributes of Distal Convoluted Tubule Cells
PRJNA949574 | ENA
ProteomicsProteomic analysis of isolated mouse distal convoluted tubules following high potassium or low sodium diet
The “aldosterone paradox” is a poorly understood physiological mechanism in which increases in the hormone aldosterone either serve to stabilize blood pressure by increasing sodium-chloride (NaCl) reabsorption or to excrete potassium (K+). Under low NaCl intake, abundance and activity of the thiazid...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-30 | PXD014383 | Pride
Distal convoluted tubule Potassium Mouse Sodium Kidney Aldosterone 
ProteomicsAcute effects of Salbutamol in Mouse Kidney Distal Convoluted Tubules (mpkDCT) Cells
The sympathetic nervous system (SNS) plays a central role in blood pressure regulation. Recent studies have shown that cells of the distal convoluted tubule (DCT) can be stimulated directly via the beta-adrenergic receptor resulting in activation of the NaCl cotransporter NCC. Whether these effects ...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-17 | PXD019051 | Pride
Beta2-adrenergic receptor Salbutamol Hypertention Dct 
UnknownEnriched Single-Nucleus RNA-Sequencing Reveals Unique Attributes of Distal Convoluted Tubule Cells.
Not available
S-EPMC11000721 | biostudies-literature
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