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ProteomicsIn-Depth Platelet Proteomic Analysis in Various Dementia Stages: Unveiling Biomarkers for Alzheimer's Disease
Early detection of Alzheimer’s disease (AD) can provide an effective scheme to prevent the disease progression. Studies have shown that blood platelets are a useful peripheral source for AD diagnosis. Identifying proteomics-based platelet biomarkers of mild cognitive impairment (MCI) and AD related ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD067460 | Pride
Alzheimer’s disease Liquid chromatography-tandem mass spectrometry  biomarker Amyloid Mild cognitive impairment Proteomics Platelets 
ProteomicsA proteomic approach to understand the clinical significance of acute myeloid leukemia-derived extracellular vesicles reflecting essential characteristics of leukemia
Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and its overall incidence has been increasing gradually over the years. Extracellular vesicles (EVs) are known to express the properties of their parental cells, including proteins, RNAs, and DNAs. As EVs are representa...
ORGANISM(S): Homo sapiens (Human) 
2020-12-03 | PXD022758 | Pride
Proteomics Q-exactive Cell Evs Aml 
ProteomicsProteomic analysis of human follicular fluid in poor ovarian responders during in vitro fertilization
Poor ovarian response (POR) observed in controlled ovarian stimulation (COS) is often observed during in vitro fertilization and embryo transfer (IVF-ET) cycles and is a major problem. A POR has been found to be related to several factors, including advanced age, high body mass index, and history of...
ORGANISM(S): Homo sapiens (Human) 
2018-07-05 | PXD005436 | Pride
Multiple reaction monitoring Follicular fluid Biomarker Proteomics Poor ovarian response 
ProteomicsSystematic Proteome Profiling of Maternal Plasma for Development of Preeclampsia Biomarkers
Background: Preeclampsia (PE) is a hypertensive disorder of pregnancy with various clinical symptoms. However, traditional markers for the disease including high blood pressure and proteinuria are poor indicators of the related adverse outcomes. Here, we performed systematic proteome profiling of pl...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD050118 | Pride
Proteomics Plasma Preeclampsia Human 
ProteomicsCREB regulated transcriptional coactivator 2 proteome landscape is plausibly modulated by SREBF1
CRTC2 is a critical transcription cofactor that induces the glucose homeostatic genes by activating CREB. However, energy homeostasis is maintained by multiple pathways, therefore, it is possible that CRTC2 may interact with other transcription factors, especially under metabolic stress. Thereby, CR...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD039817 | Pride
Crtc2 Ppi Metabolic disorders Srebf1 Glucose homeostasis 
ProteomicsProteomic analysis reveals distinct metabolic differences between GM-CSF and M-CSF grown macrophages derived from murine bone marrow cells
Macrophages are crucial in controlling infectious agents and tissue homeostasis. Macrophages require a wide range of functional capabilities in order to fulfill distinct roles in our body, one being rapid and robust immune responses. To gain insight into macrophage plasticity and the key regulatory ...
ORGANISM(S): Mus musculus (Mouse) 
2015-08-04 | PXD002582 | Pride
Macrophage Phosphoproteins Tmt Protein identification Immunology Mass spectrometry 
ProteomicsIntegrated Analysis of Global Proteome and Phosphoproteome in Cisplatin Resistant Bladder Cancer Cell Revealed the Molecular Signature Predictive to Patient Survival
Cisplatin-based chemotherapy is the standard care regimen in bladder cancer (BC). However, resistance to the therapy whose molecular mechanisms of the resistance are not fully elucidated rapidly develops in BC patients. Here we introduced multidimensional proteomic analysis providing different level...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD005308 | Pride
Phosphoproteomics Bladder cancer Cisplatin resistance Biological network Molecular signature 
ProteomicsDiscovery of gastric cancer-specific biomarkers by the application of serum proteomics
The aims of this study are to compare the proteomes of serum samples from patients with gastric cancers and normal controls, and to develop useful tumor markers of gastric cancer by quantitative proteomic analysis
ORGANISM(S): Homo sapiens (Human) 
2017-02-08 | PXD005156 | Pride
Human Gastric cancer Serum Biomarker 
ProteomicsAlterations in lipid profile of the aging kidney identified by MALDI imaging mass spectrometry
During aging, the kidney undergoes functional and physiological changes that are closely affiliated with chronic kidney disease (CKD). There is increasing evidence supporting the role of lipid or lipid-derived mediators in the pathogenesis of CKD and other aging-related diseases. To understand the r...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-10 | PXD013860 | Pride
Ckd Lipidomics Chronic kidney disease Ims Renal fibrosis 
ProteomicsRNA-dependent solubility of Escherichia coli proteome: Structural hub, disorder, and chaperone network
Protein aggregation is a complex phenomenon involving aberrant folding and proteostasis that leads to various proteopathies. Despite extensive efforts, the maintenance of protein solubility against aggregation remains ill-defined, especially in complex cellular environments. In this study, we show t...
ORGANISM(S): Escherichia coli 
2024-05-24 | PXD040618 | Pride
Rna Chaperone Aggregation Protein folding Proteomics Lc-ms/ms 
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