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ProteomicsIdentification and functional annotation of the Src-regulated kinome, part 2
Despite significant progress, our understanding of how specific oncogenes transform cells is still limited and likely underestimates the complexity of downstream signalling events. Herein, we describe a novel, integrated approach that addresses this knowledge gap. This utilizes mass spectrometry-bas...
ORGANISM(S): Homo sapiens (Human) 
2018-11-21 | PXD011146 | Pride
Lc-msms Kinome Phosphoproteome 
ProteomicsKinome-profiling enabled discovery of a LATS1/2 inhibitor with wound healing potential
System-level mapping of kinase inhibitors polypharmacology can uncover opportunities for drug repurposing and identify starting points for medicinal chemistry campaigns aimed at novel targets. Here, we describe a large-scale profiling of 257 kinase inhibitors that revealed domains of promiscuity, po...
ORGANISM(S): Homo sapiens (Human) 
2026-07-15 | PXD073488 | Pride
Human Proteomics Kinase selectivity profiling Kinase inhibitor 
ProteomicsCharacterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation
Despite significant progress, our understanding of how specific oncogenes transform cells is still limited and likely underestimates the complexity of downstream signalling events. Herein, we describe a novel, integrated approach that addresses this knowledge gap. This utilizes mass spectrometry-bas...
ORGANISM(S): Homo sapiens (Human) 
2019-01-14 | PXD010687 | Pride
Breast cancer Cancer Src Kinome 
ProteomicsKinome profiling upon HCMV infection using the MIB-MS approach
Human cytomegalovirus (HCMV) is a significant cause of disease in immune-compromised adults and immune naïve newborns. No vaccine exists to prevent HCMV infection, and current antiviral therapies have toxic side effects that limit the duration and intensity of their use. There is thus an urgent need...
ORGANISM(S): Homo sapiens (Human) 
2017-03-20 | PXD005276 | Pride
Hcmv Human herpesvirus Kinase inhibitors Kinome Antivirals Virology Label-free quantitation 
ProteomicsCharacterisation of the Active Kinome of Leishmania
Background: Leishmania parasites cause neglected tropical diseases such as cutaneous and visceral leishmaniasis, which have limited treatment options and rising drug resistance. Protein kinases are pivotal in Leishmania biology and attractive drug targets, but their functional status in the parasite...
ORGANISM(S): Leishmania mexicana 
2025-12-18 | PXD066933 | Pride
Parasite Drug target Leishmania Chemoproteomics Neglected tropical disease Activity-based protein profiling Protein kinase Kinome 
UnknownKinome profiling of Arabidopsis using arrays of kinase consensus substrates.
Not available
S-EPMC1803769 | biostudies-literature
ProteomicsActive kinome in human skeletal muscle insulin resistance
Obesity-related insulin resistance (OIR) is one of the main contributors to type 2 diabetes and other metabolic diseases. Protein kinases are implicated in key signaling steps including insulin signaling and glucose metabolism. Molecular mechanisms underlying OIR involving global active kinases rema...
ORGANISM(S): Homo sapiens (Human) 
2020-01-23 | PXD011909 | Pride
Quantitative proteomics Protein kinase Human skeletal muscle Insulin resistance Active kinome 
ProteomicsMYC-dependent kinome in pancreatic cancer
We recently established the ERK-dependent transcriptome and phosphoproteome in KRAS-mutant pancreatic ductal adenocarcinoma (PDAC). Of 1,718 ERK-dependent genes, 143 encode transcription factors. Of 2,123 ERK-dependent phosphoproteins, 98 are transcription factors. Despite this complexity, we observ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-15 | PXD061413 | Pride
Mib-ms Myc Pancreatic cancer Kinome 
ProteomicsKinome Profiling of Gastrointestinal Stromal Tumors Using Multiplexed Inhibitor Beads and Mass Spectrometry Identifies Wee1 as a Candidate Therapeutic Target
Purpose: Management of gastrointestinal stromal tumor (GIST) has been revolutionized by the identification of activating mutations in KIT and PDGFRA and the clinical application of receptor tyrosine kinase (RTK) inhibitors in the advanced disease setting. Stratification of GIST into molecularly defi...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020720 | Pride
Gastrointestinal stromal tumor Pdgfra Kit 
ProteomicsCharacterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling
Kinome profiling of human basal breast cancer cell line MDA-MB-231 using CTx-0294885 or mixture of 4 broad-spectrum kinase inhibitor (Purvalanol B, SU6668, VI16832 and CTx-0294885). Kinase enrichment utilizing broad-spectrum kinase inhibitors enables the identification of large proportions of the ex...
ORGANISM(S): Homo sapiens (Human) 
2013-06-06 | PXD000239 | Pride
Mda-mb-231 Kinome profiling Ctx-0294885 Lcmsms 
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