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ProteomicsA lipopolysaccharide-dependent phage infects a pseudomonad phytopathogen and can evolve to evade phage resistance
Bacterial pathogens are major causes of crop diseases, leading to significant production losses. For instance, kiwifruit canker, caused by the phytopathogen Pseudomonas syringae pv. actinidiae (Psa), has posed a global challenge to kiwifruit production. Treatment with copper and antibiotics, whilst ...
ORGANISM(S): Pseudomonas phage PaMx74 
2025-08-05 | PXD035071 | Pride
Psa phage proteomics Cryo-electron microscopy Phage biocontrol Structural proteome φpsa374 
TranscriptomicsEndothelial cell response to trophoblastic debris
The human placenta is covered by a single multinucleated fetal cell, the syncytiotrophoblast, which is bathed in maternal blood. During all pregnancies, membrane enclosed extracellular vesicles derived from the syncytiotrophoblast are extruded into the maternal blood.The large size of these extracel...
ORGANISM(S): Homo sapiens 
2016-08-21 | E-GEOD-69996 | biostudies-arrayexpress
ProteomicsImmune cell proteomes of Long COVID patients have functional changes similar to those in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
To investigate the pathophysiology of Long COVID (LC), a pilot study of patients and healthy controls has used quantitative proteomics to discover changes in peripheral blood mononuclear cell (PBMC) proteoms. The proteomes of LC patients and healthy controls were analysed by Sequential Window Acquis...
ORGANISM(S): Homo sapiens (Human) 
2025-08-05 | PXD045508 | Pride
Me/cfs Swath-ms Long covid 
ProteomicssAPP a neuroprotective protein in the brain has widespread effects on the proteome of human cortical neurons related to memory mechanisms.
Human glutamatergic neurons in culture were exposed to 1 nM secreted amyloid precursor protein alpha over a time course (0, 2, 6 and 24 h) and changes in the proteome were identified with SWATH-MS.
ORGANISM(S): Homo sapiens (Human) 
2022-04-03 | PXD031704 | Pride
App Alzheimer’s disease Proteome. Sappa Human neuron 
UnknownThe G82S polymorphism promotes glycosylation of the receptor for advanced glycation end products (RAGE) at asparagine 81: comparison of wild-type rage with the G82S polymorphic variant.
Not available
S-EPMC3122198 | biostudies-literature
UnknownThe exon-intron gene structure upstream of the initiation codon predicts translation efficiency.
Not available
S-EPMC5961209 | biostudies-literature
ProteomicsThe brain protein secreted amyloid precursor protein alpha (sAPPalpha) regulates neurologically-important proteins of the cellular proteome and secretome of mouse primary astrocytes
Mouse primary astrocytes in culture were exposed to 1 nM secreted amyloid precursor protein alpha (sAPPalpha) or PBS (control) for 2 h or 6 h and changes in the cellular proteome or secretome respectively were quantified by SWATH-MS.
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD037902 | Pride
Astrocytes Amyloid precuror protein Proteome Secretome 
ProteomicsProteomic analysis of cervicovaginal fluid for endometriosis biomarker discovery
Endometriosis is a gynaecological disease facing significant diagnostic challenges, contributing to an extensive diagnostic delay. Non-invasive diagnostic biomarkers of endometriosis could expedite diagnosis and minimise the reliance on surgery to confirm endometriosis. This pilot study aimed to ide...
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD065951 | Pride
Cervicovaginal fluid Endometriosis Swath-ms 
ProteomicsZNRF3 and RNF43 are active monomeric E3 ligases that self-associate
Crosslinking mass spectrometry was used to identify the site of dimerization in the RING domain of ZNRF3. The two proteins, ZNRF3 and RNF43 have a key role in regulating the number of Frizzled (FZD) receptor on cells and their inactivation causes cancer. This is because they are RING E3 ligases that...
ORGANISM(S): Homo sapiens (Human) 
2026-07-30 | PXD070424 | Pride
Znrf3 e3 ligase Cross-linking Ring dimerization 
UnknownA pilot study on the immune cell proteome of long COVID patients shows changes to physiological pathways similar to those in myalgic encephalomyelitis/chronic fatigue syndrome.
Not available
S-EPMC10716514 | biostudies-literature
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