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UnknownA Reliable Approach for Revealing Molecular Targets in Secondary Ion Mass Spectrometry.
Not available
S-EPMC9103194 | biostudies-literature
UnknownInfluence of Subcellular Localization and Functional State on Protein Turnover.
Not available
S-EPMC8306977 | biostudies-literature
UnknownComprehensive transcriptome analysis reveals altered mRNA splicing and post-transcriptional changes in the aged mouse brain.
Not available
S-EPMC11014377 | biostudies-literature
UnknownProtein lifetimes in aged brains reveal a proteostatic adaptation linking physiological aging to neurodegeneration.
Not available
S-EPMC9122331 | biostudies-literature
UnknownThe long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43.
Not available
S-EPMC6920028 | biostudies-literature
ProteomicsThe long noncoding RNA neuroLNC modulates neurotransmitter release interacting with a neurodegeneration-associated protein
The roles of long noncoding RNAs (lncRNAs) in synaptic transmission and neuronal development are emerging. Here we applied an integrated bioinformatic/biological screening strategy to identify lncRNAs that regulate synaptic vesicle release. We identified neuroLNC, a conserved neuron-specific nuclear...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-05-26 | PXD013434 | Pride
Neuron Ellps Cerebellum Metabolic labeling Brain turnover Cortex Protein lifetimes Glia 
ProteomicsPrecisely measured protein lifetimes in the brain of aged mice
Aging, which is associated with protein homeostasis defects, is one of the most prominent risk factors for neurodegenerative disorders and the regulation of protein homeostasis is essential for brain health. While several studies have addressed changes in protein abundance due to aging, little is kn...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD023994 | Pride
Synapse Cerebellum Metabolic labeling Brain turnover Cortex Protein lifetimes 
UnknownExtracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R.
Not available
S-EPMC8654841 | biostudies-literature
UnknownProteo-transcriptomic reprogramming and resource reallocation define the aging mammalian brain.
Not available
S-EPMC12393264 | biostudies-literature
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