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ProteomicsCowpox virus proteomics reveals massive ubiquitination and proteasomal degradation of viral proteins but stable virus cores
The ubiquitin-proteasome system (UPS) is essential for replication of Orthopoxviruses (OPV) like vaccinia and cowpox virus (CPXV). Although several proteome studies identified ubiquitin as part of OPV particles, distinct modification sites are largely unknown. Moreover, the UPS plays a key role in p...
ORGANISM(S): Cowpox virus Cowpox virus (CPV) 
2018-02-07 | PXD006426 | Pride
Ubiquitination Viral proteomics Orthopoxvirus 
ProteomicsComparison of the Cowpox Virus and Vaccinia Virus Mature Virion Proteome: Analysis of the species- and strain-specific Proteome
Cowpox virus (CPXV) causes most zoonotic orthopoxvirus (OPV) infections in Europe and Northern as well as Central Asia. The virus has the broadest host range of OPV and is transmitted to humans from rodents and other wild or domestic animals. Increasing numbers of human CPXV infections in a populati...
ORGANISM(S): Orthopoxvirus 
2015-11-16 | PXD003013 | Pride
Ltq-orbitrap Virion proteome Orthopoxvirus 
ProteomicsCombined proteomics/genomics approach reveals proteomic changes of mature virions as a novel poxvirus adaption mechanism
DNA viruses, like poxviruses, possess a highly stable genome, suggesting adaption of virus particles to specific cell types is not restricted to genomic changes. Cowpox viruses (CPXV) are zoonotic poxviruses with an extraordinary broad host range, demonstrating their adaptive potential in vivo. To e...
ORGANISM(S): Cowpox virus (CPV) 
2017-11-14 | PXD007567 | Pride
Poxvirus Adaption Cowpox virus Lc-ms/ms 
ProteomicsDeep time-course proteomics of SARS-CoV and SARS-CoV-2 infected human lung epithelial cells (Calu-3) reveals strong induction of interferon-stimulated gene (ISG) expression by SARS-CoV-2 in contrast to SARS-CoV
In the present study, we used data-independent acquisition mass spectrometry (DIA-MS) to analyse the protein expression in Calu-3 cells infected with SARS-CoV and SARS-CoV-2 over the time-course of 24 hours. About 8400 proteins were identified, from which about 90% could be quantified across the exp...
ORGANISM(S): Homo sapiens (Human) Severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome-related coronavirus 
2022-01-20 | PXD024883 | Pride
Sars-cov-2 Sars-cov Calu-3 Human lung cells 
ProteomicsProtein aggregation is a consequence of the dormancy-inducing membrane toxin TisB in Escherichia coli
Protein aggregates occur in all living cells due to misfolding of proteins. In bacteria, protein aggregation is associated with cellular inactivity, which is related to dormancy and tolerance to stressful conditions, including the exposure to antibiotics. In Escherichia coli, the membrane toxin TisB...
ORGANISM(S): Escherichia coli 
2024-10-04 | PXD049478 | Pride
Toxin-antitoxin system Antibiotics Dormancy Protein aggregation Type i toxin 
ProteomicsTriggered offset fragmentation allows massively multiplexed target profiling on quadrupole-orbitrap mass spectrometers
Parallel reaction monitoring (PRM) on quadrupole-orbitrap mass spectrometers has a limited multiplexing capacity which depends heavily on the reproducibility of peptide retention times. To overcome these limitations, we aimed to establish a data acquisition mode that allows retention-time-independen...
ORGANISM(S): Candida albicans (Yeast) Homo sapiens (Human) 
2020-06-19 | PXD017778 | Pride
Prm Multiplexing Targeted proteomics Quantification Lc-ms/ms 
ProteomicsThe translational landscape of HIV-1 infected cells reveals novel gene regulatory principles
Human Immunodeficiency Virus-1 (HIV-1) uses a number of strategies to modulate viral and host gene expression during its lifecycle. To characterize the transcriptional and translational landscape of HIV-1 infected cells, we used a combination of ribosome profiling, disome sequencing and RNA sequenci...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD058232 | Pride
Hiv-1 Ribosome profiling Disome profiling Rna sequencing Lc-ms/ms 
UnknownSocio-economic inequalities in body mass index among preschool children: do sports programs in early childhood education and care centers make a difference?
Not available
S-EPMC10325856 | biostudies-literature
TranscriptomicsTranscription profiling of human TLR2/1 stimulated human monocytes with the Mycobacterium tuberculosis derived 19kDa lipopeptide reveals Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial activity against intracellular bacteria, which in murine, but not human, monocytes and macrophages is mediated principally by nitric oxide. We report here that TLR activation of human macrophages up-re...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-8921 | biostudies-arrayexpress
ProteomicsDisassembly of Functional Membrane Microdomains Relapses Antibiotic Resistance in Staphylococcus aureus
Bacteria spatially confine cellular processes like protease secretion and signal transduction in membrane platforms termed functional membrane microdomains, which in certain organisational and functional features resemble the lipid rafts of eukaryotic cells. However, a rigorous understanding of thei...
ORGANISM(S): Staphylococcus aureus 
2019-01-08 | PXD006546 | Pride
Drm Dsm Membrane platforms Staphylococcus aureus Lc-ms/ms 
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