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ProteomicsVEGF orchestration of the p130Cas Interactome
p130Cas is a polyvalent adapter protein essential for cardiovascular development, and with a key role in cell movement. In order to identify the pathways by which p130Cas exerts its biological functions in endothelial cells we mapped the p130Cas interactome and its dynamic changes in response to VEG...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080860 | MassIVE
ProteomicsInteractome dynamics of RAF1-BRAF kinase monomers and dimers
RAF kinases play major roles in cancer. BRAFV600E mutants drive ~6% of human cancers. Potent kinase inhibitors exist but show variable effects in different cancer types, sometimes even inducing paradoxical RAF kinase activation. Both paradoxical activation and drug resistance are frequently due to e...
ORGANISM(S): Homo sapiens (Human) 
2023-02-27 | PXD036792 | Pride
Raf1 Braf Dimerization Raf kinase Interactome 
ModelsReiterer2013 - pseudophosphatase STYX role in ERK signalling
Reiterer2013 - pseudophosphatase STYX role in ERK signalling This model is described in the article: Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2. Reiterer V, Fey D, Kolch W, Kholodenko BN, Farhan H. Proc. N...
2024-09-02 | BIOMD0000000557 | BioModels
ProteomicsVEGF orchestration of the p130Cas Interactome
p130Cas is a polyvalent adapter protein essential for cardiovascular development, and with a key role in cell movement. In order to identify the pathways by which p130Cas exerts its biological functions in endothelial cells we mapped the p130Cas interactome and its dynamic changes in response to VEG...
ORGANISM(S): Homo sapiens (Human) 
2017-01-02 | PXD003902 | Pride
Mass spectrometry Neuropilin Iqgap1 Cell movement Focal adhesion 
Proteomics(AP-MS) Kinase Suppressor of RAS 1 (KSR1) maintains the transformed phenotype of BRAFV600E mutant human melanoma cells
KSR1 is a scaffolding protein for the RAS-RAF-MEK-ERK pathway, which is one of the most frequently altered pathways in human cancers. Previous results have shown that KSR1 has a critical role in mutant RAS mediated transformation. Here, we examined the role of KSR1 in mutant BRAF transformation. We ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD036261 | Pride
Ksr1 Ras_raf-mek-erk pathway Melanoma Apoptosis Proliferation Senescence 
Proteomics(Full Proteome) Kinase Suppressor of RAS 1 (KSR1) maintains the transformed phenotype of BRAFV600E mutant human melanoma cells
KSR1 is a scaffolding protein for the RAS-RAF-MEK-ERK pathway, which is one of the most frequently altered pathways in human cancers. Previous results have shown that KSR1 has a critical role in mutant RAS mediated transformation. Here, we examined the role of KSR1 in mutant BRAF transformation. We ...
ORGANISM(S): Homo sapiens (Human) 
2023-08-15 | PXD036265 | Pride
Ksr1 Proteomics. Ras-raf-mek-erk pathway Cancer 
ModelsNguyenLK2011 - Ubiquitination dynamics in Ring1B/Bmi1 system
NguyenLK2011 - Ubiquitination dynamics in Ring1B-Bmi1 system This theoretical model investigates the dynamics of Ring1B/Bmi1 ubiquitination to identify bistable switch-like and oscillatory behaviour in the system. Michaelis-Menten (MM) equations are used to formulate the model. However, the authors ...
2024-09-02 | BIOMD0000000622 | BioModels
ModelsSchilling2009 - ERK distributive
Schilling2009 - ERK distributive This model has been exported from PottersWheel on 2009-04-20 18:57:44.  The PottersWheel Model Definition file can be obtained from the curation tab. This model is described in the article: Theoretical and experimental analysis links ...
2024-09-02 | BIOMD0000000270 | BioModels
ModelsKim2007 - Crosstalk between Wnt and ERK pathways
Kim2007 - Crosstalk between Wnt and ERK pathways Experimental studies have shown that both Wnt and the MAPK pathways are involved in the pathogenesis of various kinds of cancers (eg. colorectal cancer). The crosstalk between the two pathways have also been identified. Here, Kim et ...
2024-09-02 | BIOMD0000000149 | BioModels
TranscriptomicsRNA-Sequencing of vemurafenib-sensitive and resistant melanoma cell line SKMEL-239
RNA-seq data were generated for two conditions: for parental SK-MEL-239 cells grown in normal media and resistant SK-MEL-239 cells grown in media supplemented with vemurafenib.
ORGANISM(S): Homo sapiens 
2022-04-16 | E-MTAB-11609 | biostudies-arrayexpress
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