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ProteomicsFidelity of translation initiation is required for coordinated respiratory complex assembly
Mammalian mitochondrial ribosomes are unique molecular machines that translate 11 leaderless mRNAs. To date it is not clear how mitoribosomes recognize and initiate translation in the absence of untranslated regions in the mitochondrial mRNAs. Translation initiation in mitochondria shares similariti...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-02 | PXD015521 | Pride
Ribosome Translation Cardiomyopathy Rna-seq 
ProteomicsMitochondrial mistranslation is modulated by metabolic stress
Changes in the rate and fidelity of mitochondrial protein synthesis impact the metabolic and physiological roles of mitochondria. Here we explored how environmental stress in the form of a high fat diet modulates mitochondrial translation using mutant mice with error-prone (Mrps12ep/ep) or hyper-acc...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD021762 | Pride
Metabolism Mitochondria Protein synthesis 
ProteomicsCysteine alkylating methods in shotgun proteomics and their possible effects on methionine residues
Neatly every proteomic protocol has a Cysteine reduction and alkylation step in it preceding the trypsin digestion. It needs to be done in order to remove the s-s bonds and prevent proteins from folding, thus, provide better access for trypsin. Among various reagents used for alkylation, iodoacetami...
ORGANISM(S): Homo sapiens (Human) 
2020-10-28 | PXD013973 | Pride
Cysteine Proteomics Alkylation Methionine 
ProteomicsCysteine alkylating methods in shotgun proteomics and their possible effects on methionine residues
Neatly every proteomic protocol has a Cysteine reduction and alkylation step in it preceding the trypsin digestion. It needs to be done in order to remove the s-s bonds and prevent proteins from folding, thus, provide better access for trypsin. Among various reagents used for alkylation, iodoacetami...
ORGANISM(S): Homo sapiens (Human) 
2024-02-14 | PXD015889 | Pride
Cysteine Proteomics Alkylation Methionine Reduction 
UnknownChromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cells.
Not available
S-EPMC4614355 | biostudies-literature
ProteomicsPhospho Proteomics Study for Mouse MLE15 Cell Infected by Influenza Virus
Phospho Proteomics Study from Pan-Tyrosine antibody enrichment and iMac-Fe3+ enrichment for Mouse MLE15 Cell Infected by Influenza Virus
ORGANISM(S): Mus musculus (Mouse) 
2019-06-03 | PXD009634 | Pride
Tyrosine Imac Imac Phospho Antibody Influenza virus Mouse mle15 Lc-ms/ms 
ProteomicsStress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation
The fidelity of translation is crucial in prokaryotes and for the nuclear-encoded proteins of eukaryotes, however little is known about the role of mistranslation in mitochondria and its effects on metabolism. We generated yeast and mouse models with error-prone and hyperaccurate mitochondrial trans...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-08 | PXD015456 | Pride
Oxidative phosphorylation Mitochondrial ribosome  mrps12 Stress response abbreviations used: mitoribosome Mitochondrial ribosomal protein of the small subunit 12  oxphos Mitochondria Metabolism Protein synthesis 
ProteomicsProteogenomics of adenosine-to-inosine RNA editing in fruit fly
This dataset is a part of a bigger work on RNA editing in D. melanogaster brain. We present Orbitrap spectra searched against a customized database of Drosophila proteome with introduction of variants provided by RNA editing. Tree files reflect 3 technical replicates.
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-03-13 | PXD004949 | Pride
Proteomics Ls-msms Rna editing Drosophila melanogaster 
ProteomicsProteomic analysis of rainbow trout (Oncorhynchus mykiss) exposed to microplastics
The pollution of the environment with microplastics has been recognized as an emerging threat worldwide. Due to an exponential increase in production of plastic over the last eight decades and its longevity in the environment, accumulating amounts of microplastic are polluting rivers, lakes and the ...
ORGANISM(S): Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 
2022-08-08 | PXD033331 | Pride
Q exactive hf-x Liver Oncorhynchus mykiss Microplastics Rainbow trout 
ProteomicsTranscriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals
Abstract Dysfunction of the oxidative phosphorylation (OXPHOS) system is a major cause of human disease and the cellular consequences are highly complex. Here, we present comparative analyses of mitochondrial proteomes, cellular transcriptomes and targeted metabolomics of five knockout mouse strains...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-09 | PXD035880 | Pride
Mitochondria Coenzyme q Lfq Mouse 
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