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ProteomicsGut microbiome dysregulation is associated with elevated toxic bile acids in Parkinson’s disease
The gut microbiome can impact brain health and is altered in Parkinson’s disease (PD) patients. The vermiform appendix is a lymphoid tissue implicated in the storage and regulation of the gut microbiome. Here, we investigate changes in the functional microbiome in the appendix of PD patients relativ...
ORGANISM(S): Homo sapiens (Human) 
2021-01-28 | PXD020988 | Pride
Appendix Microbiome Gut Bile acids Parkinson’s disease 
ProteomicsSynaptosome proteome IGF2 enhancer knockout mice
We identified an enhancer element near IGF2 locus that is possibly involved with dopamine function and schizophrenia. A knockout mouse was generated for the enhancer element in the IGF2 locus. We then characterized the striatal synaptosomes ( i.e. biological fraction representing pre- post synaptic ...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-31 | PXD012786 | Pride
Dopamine Schizophrenia Striatum Synaptosome Igf2 
ProteomicsEpigenetic contributions to hemisphere asymmetry in healthy brain, aging, and Parkinson’s disease
Hemispheric asymmetry in neuronal processes is a fundamental feature of the human brain and drives symptom lateralization in Parkinson's disease (PD), but its molecular determinants are unknown. Here, we determine epigenetic changes and genes involved in hemispheric asymmetry in the healthy and PD b...
ORGANISM(S): Homo sapiens (Human) 
2020-03-26 | PXD015239 | Pride
Enhancer Neurons Epigenetics Parkinson’s disease Hemisphere asymmetry Aging 
ProteomicsEpigenetic inactivation of the autophagy-lysosomal system in the Parkinson’s disease appendix
The gastrointestinal tract may be a site of origin for α-synuclein (α-syn) pathology in idiopathic Parkinson’s disease (PD), and an abundance of aggregated α-syn has recently been demonstrated in both the healthy and PD appendix. However, the molecular changes that enable gut α-syn aggregates to con...
ORGANISM(S): Homo sapiens (Human) 
2020-02-18 | PXD015079 | Pride
Appendix Neurons Autophagy Lysosome Parkinson’s disease Epigenetic 
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