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GenomicsDIABIMMUNE Transcriptomics DAC
Data Access Committee EGAC00001001443
EGAC00001001443 | EGA
ProteomicsBALF exosomes - Pulmonary Sarcoidosis is Associated With Exosomal Vitamin D-Binding Protein and Inflammatory Molecules
Using 8-plex iTRAQ labelling exosmes isolated from bronchial lavage (BALF) were analyzed by LC-MS/MS. The measurements compared control subjects with sarcoidosis patients (15 in all) ; five with löfgrens syndrome and 10 with regular sacroidosis
ORGANISM(S): Homo sapiens (Human) 
2016-09-27 | PXD001808 | Pride
Sarcoidosis Exosome Balf 
TranscriptomicsTranscription profiling of human Th cells induced to polarize to Th1 or Th2 direction in the presence or absence of TGFbeta
Th1 and Th2 cells arise from a common precursor cell in response to triggering through the TCR and cytokine receptors for IL-12 or IL-4. This leads to activation of complex signaling pathways, which are not known in detail. Disturbances in the balance between type 1 and type 2 responses can lead to ...
ORGANISM(S): Homo sapiens 
2007-12-12 | E-GEOD-2770 | biostudies-arrayexpress
ProteomicsSerum proteomics of Premature Carotid atherosclerosis: The Cardiovascular Risk in Young Finns Study
Cardiovascular diseases represent a leading cause of deaths globally; of which atherosclerosis is a major contributor. Selective retention of circulating apolipoprotein B particles in the sub endothelial space by arterial wall proteoglycans and their subsequent modification is currently thought to b...
ORGANISM(S): Homo sapiens (Human) 
2018-07-30 | PXD008278 | Pride
Atherosclerosis Serum Label free quantification Protoemics 
ProteomicsCIP2A interactome in human Th17 Cells
CIP2A immunoprecipitation (IP) was carried out with two specific anti CIP2A antibodies that recognize distinct regions of CIP2A protein and respective Immunoglobulin G (IgG) were used in control IPs as a negative control. The digested samples were analyzed by LC-MS/MS to identify CIP2A protein netwo...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD008983 | Pride
Th17 cells Cord blood Cip2a Interactome Lc-ms/ms 
TranscriptomicsPreprocessed reduced representation bisulfite sequencing (RRBS) data from 173 human umbilical cord blood samples, collected for a study on associations between perinatal DNA methylation marks and progression to type 1 diabetes by age 15
The samples were collected from the participants of the Finnish Diabetes Prediction and Prevention (DIPP) Study, born between 1995 and 2006. DIPP is a prospective follow-up cohort of children with a moderate or high risk of type 1 diabetes, based on the HLA-DR-DQ genotype. Islet cell autoantibodies ...
ORGANISM(S): Homo sapiens 
2022-06-06 | E-MTAB-10530 | biostudies-arrayexpress
ProteomicsHIC1 interacts with FOXP3 multi protein complex: a novel mechanism to regulate human regulatory T cell differentiation and function
Recent data have shown that Hypermethylated in cancer 1 (HIC1) is an important contributor to iTreg cell development and function. Using affinity-purification and tandem mass spectrometry we systematically characterized the HIC-1 interactome in human iTreg cells. On the basis of these data, we have ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-16 | PXD039337 | Pride
Hic1  interactome  immunoprecipitation  proteomics  foxp3  protein complex  runx1  regulatory t cells  t cell differentiation  tgf-β  treg  itreg. 
ProteomicsMinigut Cellular Proteome and Secretome
A mouse minigut Organoid model analysed using quantitative proteomics to measure proteins expressed in the crypt and villi –like cellular states, additionally providing novel details of the secreted proteins associated with these conditions.
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD023737 | Pride
Lc-ms/ms Celiac disease 
ProteomicsCIP2A negatively regulates Th17 differentiation
Interleukin 17 (IL-17) producing T helper 17 (Th17) cells are critical drivers of pathogenesis in a variety of autoimmune and inflammatory diseases. Strategies to mitigate excessive Th17 response thus remain an attractive target for immunotherapies. Here we report that Cancerous Inhibitor of Protein...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD010612 | Pride
Th17 cell differentiation Stat3 phosphorylation 
ProteomicsPhenotypic profiling of human induced regulatory T cells at early differentiation: insights into distinct immunosuppressive potential
Regulatory T cells (Tregs) play a key role in suppressing systemic effector immune responses, thereby preventing autoimmune diseases but could also potentially contribute to tumor progression. As a result, there is significant interest in the clinical manipulation of Tregs. However, the mechanisms g...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052626 | Pride
Faims Dia Foxp3 Treg T cell differentiation Cd103 
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