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ProteomicsCx37 Phosphorylation and cell cycle regulation
Using alanine and aspartate substitutions to mimic dephosphorylated and phosphorylated Cx37, respectively, we showed that induced expression of Cx37 in rat insulinoma cells could arrest cell cycle progression, support cell cycle progression or cause cell death in a phosphosite specific manner. In th...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-13 | PXD012191 | Pride
Gap junction  growth arrest  proliferation  cell death  differential phosphorylation 
ProteomicsThe CLASP2 Protein Interaction Network in Adipocytes Links CLIP2 to AGAP3, CLASP2 to G2L1, MARK2, and SOGA1, and Identifies SOGA1 as a Microtubule-Associated Protein
CLASP2 is a microtubule-associated protein that undergoes insulin-stimulated phosphorylation and co-localization with reorganized actin and GLUT4 at the plasma membrane. To gain insight to the role of CLASP2 in this system, we developed and successfully executed a streamlined interactome approach an...
ORGANISM(S): Mus musculus (Mouse) 
2017-06-01 | PXD003674 | Pride
Ap-ms Mark2 G2l1 Interactome Saint Soga1 Clip2 Agap3 Clasp2 
ProteomicsInsulin Induces Microtubule Stabilization and Regulates the Microtubule Plus-End Tracking Protein Network in Adipocytes
Insulin-stimulated glucose uptake is known to involve microtubules, although the function of microtubules and the microtubule-regulating proteins involved in insulin action are poorly understood. CLASP2, a plus-end tracking microtubule-associated protein (+TIP) that controls microtubule dynamics, wa...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2019-06-13 | PXD011431 | Pride
Clasp2 g2l1 insulin microtubules 
ProteomicsInhibition of spinal cord Hsp90 enhances morphine anti-nociception by activating an ERK/RSK pathway
Morphine and other opioids continue to be commonly utilized as clinical analgesics, despite their numerous adverse side effects, including respiratory depression, addiction, and tolerance. The modulation of µ-opioid receptor (MOR) signaling and subsequent behavioral output is one viable approach to ...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-24 | PXD015060 | Pride
Hsp90 Anti-nociception Erk Spinal cord 
ProteomicsA single mutation in NFU1 gene metabolically reprograms pulmonary artery smooth muscle cells
NFU1 is an iron-sulfur (Fe-S) scaffold protein, involved in Fe-S assembly and transfer to a range of mitochondrial metalloproteins. Patients with the NFU1G208C mutation develop pulmonary arterial hypertension (PAH) with 70% penetrance. Rats with NFU1G206C homozygous mutation demonstrated the PAH phe...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-08 | PXD015022 | Pride
Nfu1 Pulmonary arterial hypertension Hyper-proliferative Liver 
ProteomicsTransmembrane protein 184B (TMEM184B) promotes endolysosomal acidification through vesicular proton pump regulation
Disruption of endolysosomal acidification is a hallmark of several neurodevelopmental and neurodegenerative disorders. Impaired acidification causes accumulation of toxic protein aggregates and disrupts neuronal homeostasis, yet the molecular mechanisms regulating endolysosomal pH in neurons remain ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-16 | PXD064977 | Pride
Vatpase Endolysosomal acidification Tmem184b 
ProteomicsEffect of mitochEffect of mitochondrial complex III chronic inhibition on mitochondrial proteomic landscapeondrial complex III chronic inhibition on mitochondrial proteomic landscape
The mitochondria play a vital role in controlling cell metabolism and regulating crucial cellular outcomes. We previously demonstrated that chronic inhibition of the mitochondrial complex III in rats by Antimycin A (AA) induced pulmonary vasoconstriction. On the metabolic level, AA-induced mitochond...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-09 | PXD020551 | Pride
Antimycin a Pulmonary vasoconstriction Mitochodria Quantitative proteomics 
ProteomicsAltered Transcription Factor Expression Responses to Exercise in Insulin Resistance
Purpose. Insulin resistant muscle is resistant to gene expression changes induced by acute exercise. This study was undertaken to identify transcription factors that differentially respond to exercise in insulin resistance. Candidate transcription factors were identified from analysis of 5’-untransl...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD023354 | Pride
Insulin resistance Skeletal muscle Exercise Gene expression Transcription factors 
ProteomicsNonequilibrium Thermodynamics and Mitochondrial Protein Content Predict Insulin Sensitivity and Fuel Selection During Exercise in Human Skeletal Muscle
Introduction. Many investigators have attempted to define the molecular nature of changes responsible for insulin resistance in muscle, but a molecular approach may not consider the overall physiological context of muscle. Because the energetic state of ATP (ΔGATP) could affect the rate of insulin-s...
ORGANISM(S): Homo sapiens (Human) 
2023-06-29 | PXD043032 | Pride
31p-magnetic resonance spectroscopy Exercise Mitochondria Skeletal muscle Insulin sensitivity Fuel selection 
Proteomics: The effects of chronic morphine on the endogenous cannabinoid system in the ventral tegmental area
The United States is currently facing a severe opioid epidemic, therefore addressing how opioids induce rewarding behaviors could be key to a solution for this medical and societal crisis. Recently, the endogenous cannabinoid system has emerged as a hot topic in the study of opioid reward but relati...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-04-08 | PXD023096 | Pride
Ventral tegmental area Cannabinoid receptors Endocannabinoids Opioid Reward Endogenous cannabinoid system 
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