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ProteomicsLPS-stimulated endothelial cells using SILAC
Severe sepsis and septic shock, which occur with high incidence and are prevalent in the emergency department setting, are among the most common causes of death in hospitalized patients worldwide, and there has been a continuous increase in the incidence of sepsis of approximately 5–10% per year. En...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-10 | MSV000081707 | MassIVE
ProteomicsLPS-stimulated endothelial cells using SILAC
Severe sepsis and septic shock, which occur with high incidence and are prevalent in the emergency department setting, are among the most common causes of death in hospitalized patients worldwide, and there has been a continuous increase in the incidence of sepsis of approximately 5–10% per year. En...
ORGANISM(S): Homo sapiens (Human) 
2015-10-05 | PXD002220 | Pride
Sepsis Silac Secretome Biomarker Moesin 
Proteomicsmouse liver microsomes phosphorylation
The microsomes are re-formed vesicle-like artifacts, not ordinarily present in living cells, from pieces of the endoplasmic reticulum (ER), plasma membrane, mitochondria, and Golgi apparatus of broken eukaryotic cells. Typically, microsomes are separated by differential centrifuged from homogenized ...
ORGANISM(S): Mus musculus (Mouse) 
2015-08-24 | PXD002221 | Pride
Mouse Phosphorylation Microsome Liver 
ProteomicsQuantitative proteomic and lipidomic analysis of LNCaP and C4-2 cell lines during CRPC progression
Prostate cancer (PCa) is one of the most common cancers diagnosed in men in the world. The majority of patients develop resistant to androgen deprovation therapy, leading to castration-resistant PCa (CRPC). CRPC have a poorer prognosis and developing metastasis compared to hormone-sensitive PCa. To ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD056553 | Pride
Human Prostate cancer Proteomics Lipidomics Gc-ms/ms Lc-ms/ms 
ProteomicsZebrafish embryo_phosphorylation_18O labeling
The zebrafish (Danio rerio) is a popular animal model in studies of vertebrate development and organogenesis. Recent research has shown a similarity of approximately 70% between the human and zebrafish genomes and of 84% in human disease-causing genes, specifically. Zebrafish embryos have a number o...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2015-10-14 | PXD002232 | Pride
: zebrafish embryo 18o labeling Global phosphoproteome 
ProteomicsCharacterization of complement C3 as a marker of alpha-amanitin toxicity by comparative secretome profiling
In the human body, proteins secreted into peripheral blood vessels are known as the secretome, and they represent the physiological or pathological status of cells. The unique response of cells to toxin exposure can be confirmed via secretome analysis, which can be used to discover toxic mechanisms ...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD038016 | Pride
Alpha-amanitin  toxic mushroom  secretomes  exposure marker  complement component 3 
ProteomicsCharacterization of hepatocytes secretomes after alpha-amanitin exposure by quantitative proteomics
In the human body, proteins secreted into peripheral blood vessels are known as the secretome, and they serve as a representation of the physiological or pathological status of cells. The unique response of cells to toxin exposure can be confirmed via secretome analysis, which can be applied to disc...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD036476 | Pride
Alpha-amanitin  toxic mushroom  secretomes  exposure marker  complement component 3 
ProteomicsCharacterization of RAS/RAF/ERK signal cascade as a novel regulating factor in alpha-amanitin-induced liver injury
The well-known hepatotoxicity mechanism resulting from alpha-amanitin (-AMA) exposure arises from RNA polymerase II (RNAP II) inhibition. RNAP Ⅱ inhibition occurs through the dysregulation of mRNA synthesis. However, the signaling pathways in hepatocytes that arise from -AMA have not yet been fully ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035758 | Pride
Alpha-amanitin  toxic mushroom  acute liver failure  global phosphoproteome  ras/raf/erk signaling pathway 
ProteomicsLC-MS/MS proteomic profiling study of ccRCC cell-lines
We conducted comparative proteomic analysis with clear cell renal cell carcinoma (ccRCC), a subtype of RCC, have poorer prognosis and metastasize to the lungs, bones and lymph nodes. Comparative proteomic analysis in ccRCC study will reveals novel insights and development of disease.
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD045898 | Pride
Ccrcc Silac Proteomic profiling 
ProteomicsCharacterization of RAS/RAF/ERK signal cascade as a novel regulating factor in alpha-amanitin-induced liver injury
The well-known hepatotoxicity mechanism resulting from alpha-amanitin (-AMA) exposure arises from RNA polymerase II (RNAP II) inhibition. RNAP Ⅱ inhibition occurs through the dysregulation of mRNA synthesis. However, the signaling pathways in hepatocytes that arise from -AMA have not yet been fully ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035817 | Pride
Alpha-amanitin  toxic mushroom  acute liver failure  global phosphoproteome  ras/raf/erk signaling pathway 
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