Sort   by:  
 Page size 
ProteomicsDevelopment of a mass-spectrometry based method for the identification of the in vivo whole blood and plasma ADP-ribosylomes
Blood and plasma proteins are heavily investigated as biomarkers for different diseases. However, the post-translational modifications of these proteins are rarely analyzed since blood contains many enzymes that rapidly remove the modification after sampling. In contrast to the well-described role o...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2021-05-26 | PXD022156 | Pride
Systemic inflammatory response syndrome Sepsis Plasma Blood Adp-ribosylation Histidine adp-ribosylation 
ProteomicsTankyrase-mediated ADP-ribosylation is a novel regulator of TNF-induced death
TNF is a key component of the innate immune response. Upon binding to its receptor, TNFR1, it promotes production of other cytokines via a membrane-bound complex 1, or induces cell death via a cytosolic complex 2. To understand how TNF-induced cell death is regulated we performed mass spectrometry o...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD032131 | Pride
Tnf-induced cell death Tankyrase Adp-ribosylation 
ProteomicsLack of the mitochondrial NAD transporter SLC25A51 redistributes NAD+ compartmentalization and cellular ADP-ribosylation
Nicotinamide adenine dinucleotide (NAD+) is a vital small molecule with important redox capacity in oxidative phosphorylation (OXPHOS) and a key co-factor in various enzymatic reactions. The recent identification of the mitochondrial NAD+ transporter SLC25A51 provides strong evidence for a direct re...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD031373 | Pride
Sl25a51 Adp-ribosylation Mitochondia 
ProteomicsPARP7-mediated ADP-ribosylation stabilizes FRA1 and restrains IRF3/IRF1-dependent apoptosis and immune signaling and in cancer cells
PARP7 inhibitors suppress tumor growth in a cell autonomous manner and by activating the immune system through restoring immune signaling. Nevertheless, the targets of PARP7-mediated ADP-ribosylation that regulate innate immune signaling and cancer cell survival remain elusive. Here, we identified P...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD041870 | Pride
Adp-ribosylation Lung cancer Parp7 Fra1 
ProteomicsMacroD1 sustains mitochondrial integrity and oxidative metabolism
The mono-ADP-ribosylhydrolase MacroD1 has recently been described to exclusively localize to mitochondria. However, to what extent and how MacroD1 controls metabolic homeostasis remains poorly understood. Here, we identify MacroD1 as a mitochondrial regulator of carbohydrate metabolism. Loss of Macr...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-05-16 | PXD020281 | Pride
Mitochondrial fission Macrod1 Mitochondrial adp-ribosylation Adp-ribosylome Glucose metabolism Label-free quantification 
ProteomicsMitochondrial ADP-ribosylation regulates NAD+-dependent genotoxic stress responses
ADP-ribosylome analysis in human U20S cells and mouse muscle tissues
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-09-08 | PXD013918 | Pride
Mitochondria U2os Adp-ribosylation Muscle 
Sort   by:  
 Page size