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ProteomicsEXPLORING THE INTERACTOME OF PML NUCLEAR SUBDOMAINS DURING FATTY ACID STRESS USING APEX2-MEDIATED PROXIMITY LABELING
When exposed to excess fatty acids, specific cell types produce nuclear lipid droplets (nLDs) that associate with promyelocytic leukemia (PML) protein to form Lipid Associated PML Structures (LAPS) that are enriched in lipid biosynthetic enzymes but deficient in canonical proteins associated with PM...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053509 | Pride
Nuclear lipid droplet Promyelocytic leukemia Copii Proximity-dependent biotin identification Apex2 Lipid-associated pml structures 
TranscriptomicsscRNAseq of freshly dissociated and cultured skin biopsies
We describe new optimised skin tissue dissociation protocol to digest ex vivo cultured and fresh human skin samples. Using scRNAseq analysis we created skin atlas composition of fresh and cultured skin samples and integrate it with other publicly available skin tissue scRNAdata to compare the qualit...
ORGANISM(S): Homo sapiens 
2022-08-04 | E-MTAB-11509 | biostudies-arrayexpress
ProteomicsIdentification of protein substrates of the Cullin-RING E3 ubiquitin ligase CRL4 through its substrate recognition factors DCAFs
Cullin-RING finger Ligases (CRLs) represent the largest family of E3 ubiquitin ligases and are responsible for ubiquitination of ~20% of cellular proteins degraded through the proteasome, catalyzing the transfer of E2-loaded ubiquitin to a substrate. Eight Cullins were described in vertebrates and a...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD037482 | Pride
Ubiquitylation Pulse-silac Dcafs Bioid Ddb1 Interactome Cullin4 
ProteomicsPulse-SILAC and interactomics reveal distinct DDB1-CUL4 associated factors (DCAFs), cellular functions, and protein substrates
Cullin-RING finger ligases (CRLs) represent the largest family of ubiquitin ligases. They are responsible for the ubiquitination of ~20% of cellular proteins degraded through the proteasome, by catalyzing the transfer of E2-loaded ubiquitin to a substrate. Seven Cullins are described in vertebrates....
ORGANISM(S): Homo sapiens (Human) 
2023-10-11 | PXD042903 | Pride
Pulse-silac Dcafs Ubiquitination Bioid Ddb1 Interactome Cullin4 
ProteomicsRibosomal protein S27A pseudogene 5 is involved in monosome related RNA translation
Pseudogenes are copies of already existing genes, and while their sequences resemble the original parental gene, they contain mutations which generally render them non-functional. However, recent advances in genome analysis suggest that pseudogenes can in fact be translated and have specific functio...
ORGANISM(S): Homo sapiens (Human) 
2026-02-03 | PXD047544 | Pride
Pseudogene Ribosome Ubiquitin Translation 
ProteomicsThe role of Wnt/β‐catenin pathway mediators in aortic valve stenosis
Aortic valve stenosis (AVS) is a prevailing and life-threatening cardiovascular disease in adults over 75 years of age. However, the molecular mechanisms governing the pathogenesis of AVS are yet to be fully unraveled. With accumulating evidence that Wnt signaling plays a key role in the development...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020783 | Pride
Calcification Immunohistochemistry Proteomics Human Real-time qpcr 
ProteomicsPhenotypic characterization of a Col6a3 knockout mouse model targeting exon 3
Mutations in COL6A3 lead to collagen VI-related myopathies due to COL6A3 loss. Therefore, studying the consequence of Col6a3 deregulated expression in mouse models is relevant, but the Col6a3 knockout mouse models currently available through a public repository does not entirely abolish COL6A3 prote...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-08 | PXD057310 | Pride
Mass spectrometry Muscular dystrophy Col6a3 Exon 3 Phenotype 
UnknownEffects of nintedanib in patients with limited cutaneous systemic sclerosis and interstitial lung disease.
Not available
S-EPMC10907814 | biostudies-literature
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