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ProteomicsMulti-omics analyses reveal that HIV-1 alters CD4 T cell immunometabolism to fuel virus replication
Human Immunodeficiency Virus type-1 (HIV-1)-infected individuals show metabolic alterations of CD4 T cells through unclear mechanisms with undefined consequences. We analyzed the transcriptome of CD4 T cells from HIV-1 patients and revealed that elevated oxidative phosphorylation (OXPHOS) pathway i...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023565 | Pride
Hiv-1 Cd4 t cell Virus replication Nlrx1 Fastkd5 Oxidative phosphorylation 
ProteomicsDifferential nuclear import sets the timing of protein access to the embryonic genome
During early embryonic cell divisions, the total nuclear volume doubles with each cycle. At a critical volume ratio between the nucleus and cytoplasm, embryos start transcribing their genome in a reproducible and sequential manner. However, the underlying molecular mechanism for these well-timed eve...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-08-30 | PXD028069 | Pride
Multiplexed quantitative proteomics Lc-ms Xenopus embryo Nucleocytoplasmic partitioning Zygotic gene activation Early embryogenesis Nuclear import 
ProteomicsDifferential nuclear import sets the timing of protein access to the embryonic genome
During early embryonic cell divisions, the total nuclear volume doubles with each cycle. At a critical volume ratio between the nucleus and cytoplasm, embryos start transcribing their genome in a reproducible and sequential manner. However, the underlying molecular mechanism for these well-timed eve...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-08-30 | PXD036403 | Pride
Multiplexed quantitative proteomics Lc-ms Xenopus embryo Nucleocytoplasmic partitioning Zygotic gene activation Early embryogenesis Nuclear import 
TranscriptomicsTranscription profiling of pancreas from rats of four strains after drinking ethanol at various concentrations for twelve months
Male rats from one of four strains (Wistar, AA, HAD or P) were housed individually in standard hanging rodent cages (Ehret, Emmendingen, Germany) on a 12-hour light-dark cycle with lights on at 07:00 a.m.. Animals were provided with food (Sniff, Soest, Germany), tap water, 5, 10 and 20% (v/v) ethano...
ORGANISM(S): Rattus norvegicus 
2009-12-31 | E-MEXP-776 | biostudies-arrayexpress
UnknownAssociation of colorectal cancer susceptibility variants with esophageal cancer in a Chinese population.
Not available
S-EPMC4462730 | biostudies-literature
UnknownTwo novel VPS33B mutations in a patient with arthrogryposis, renal dysfunction and cholestasis syndrome in mainland China.
Not available
S-EPMC3886028 | biostudies-literature
UnknownWilson disease with hepatic presentation in an eight-month-old boy.
Not available
S-EPMC4528042 | biostudies-literature
ProteomicsBlocking CXCR4+ CD4+ T cells reprograms Treg-mediated immunosuppression via modulating the Rho-GTPase/NF-κB pathway
Clinical trials have demonstrated that CXCR4 antagonists enhance the efficacy of immunotherapy in cancers by reducing regulatory T (Treg) cells, elucidating how certain mechanisms of CXCR4 in affecting Treg cells are essential for developing immunotherapeutic strategies.
ORGANISM(S): Homo Sapiens 
2024-11-25 | PXD058262 |
UnknownInfection of Common Marmosets with GB Virus B Chimeric Virus Encoding the Major Nonstructural Proteins NS2 to NS4A of Hepatitis C Virus.
Not available
S-EPMC5008089 | biostudies-literature
UnknownRelationships between cell cycle pathway gene polymorphisms and risk of hepatocellular carcinoma.
Not available
S-EPMC4917616 | biostudies-literature
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