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ProteomicsTHEM6-mediated lipid remodelling sustains stress resistance in cancer (Part3 : THEM6 KO in LNCaP AI)
Despite the clinical benefit of androgen-deprivation therapy (ADT), the majority of patients with advanced prostate cancer (PCa) ultimately develop lethal castration-resistant prostate cancer (CRPC). In this study, we identified thioesterase superfamily member 6 (THEM6) as a marker of ADT resistance...
ORGANISM(S): Homo sapiens (Human) 
2021-12-11 | PXD024433 | Pride
Castration-resistant prostate cancer Cancer metabolism Endoplasmic reticulum Cancer proteomics 
ProteomicsTHEM6-mediated lipid remodelling sustains stress resistance in cancer (Part2 : THEM6 KO in 22rv1)
Despite the clinical benefit of androgen-deprivation therapy (ADT), the majority of patients with advanced prostate cancer (PCa) ultimately develop lethal castration-resistant prostate cancer (CRPC). In this study, we identified thioesterase superfamily member 6 (THEM6) as a marker of ADT resistance...
ORGANISM(S): Homo sapiens (Human) 
2021-12-11 | PXD024456 | Pride
Castration-resistant prostate cancer Cancer metabolism Endoplasmic reticulum Cancer proteomics 
ProteomicsNucleophosmin sustains WNT-driven cell proliferation and tumour initiation in vivo
Nucleophosmin (NPM1) is a nucleolar protein frequently mutated in haematopoietic malignancies and overexpressed in many solid tumours, but little is known about its functional role in carcinogenesis. Here, we identify NPM1 as a commonly upregulated gene following APC loss in tissues that positively ...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-12 | PXD062969 | Pride
Nucleophosmin Wnt signalling Tmt16plex Colorectal cancer 
ProteomicsMitochondrial ribosomal RNA is the target of functionally dominant hotspot mutations in cancer
The vast majority of recurrent somatic mutations arising in tumors affect protein-coding genes in the nuclear genome. Here, through population-scale analysis of 14,079 whole tumor genomes, we report the discovery of highly recurrent mutations affecting both the small (12S, MT-RNR1) and large (16S, M...
ORGANISM(S): Homo sapiens (Human) 
2025-09-11 | PXD057390 | Pride
Mitochondrial dna mutation Heteroplasmy Cancer Mt-rnr1 M.1227g>a 
ProteomicsThe Mammalian Cytosolic Thioredoxin Reductase Pathway Acts via a Membrane Protein to Reduce ER-localised Proteins
Folding of proteins entering the mammalian secretory pathway requires the insertion of the correct disulfide bonds. Disulfide formation involves both an oxidative pathway for their insertion and a reductive pathway to remove incorrectly formed disulfides. Reduction of these disulfides is critical ...
ORGANISM(S): Homo sapiens (Human) 
2020-04-09 | PXD017923 | Pride
Thioredoxin reductase system Endoplasmic reticulum Sicylia redox proteomics Protein folding 
ProteomicsTumour mtDNA mutations drive aerobic glycolysis to enhance checkpoint blockade
Mitochondrial DNA (mtDNA) encodes essential machinery for respiration and metabolic homeostasis but is paradoxically among the most common targets of somatic mutations in the cancer genome, with truncating mutations in complex I genes being over-represented1 . While mtDNA mutations have been associ...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-08 | PXD039705 | Pride
Melanoma Cancer Complex i Mitochondrial dna 
ProteomicsNuclear-capture of endosomes drives depletion of nuclear G-actin to promote SRF/MRTF gene expression and cancer cell invasiveness.
Signals are relayed from receptor tyrosine kinases (RTKs) at the cell surface to effector systems in the cytoplasm and nucleus, and coordination of this process is important for the execution of migratory phenotypes, such as cell scattering and invasion. The endosomal system influences how RTK sign...
ORGANISM(S): Homo sapiens (Human) 
2021-09-28 | PXD027217 | Pride
Invasiveness Serum-response factor (srf) Cell:cell repulsion Epha2 Heptocyte growth factor (hgf) Rab17 Actin polymerisation Myocardin-related transcription factor (mrtf) Nuclear g-actin Nuclear import Pancreatic adenocarcinoma (pdac) 
ProteomicsTumour mtDNA mutations drive aerobic glycolysis to enhance checkpoint blockade (part 2)
Mitochondrial DNA (mtDNA) encodes essential machinery for respiration and metabolic homeostasis but is paradoxically among the most common targets of somatic mutations in the cancer genome, with truncating mutations in complex I genes being over-represented1 . While mtDNA mutations have been associ...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-08 | PXD044987 | Pride
Melanoma Cancer Complex i Mitochondrial dna 
ProteomicsComparative analysis of WT CBL and CBL 70Z interactomes.
Cbl (Casitas B-lineage lymphoma) is a prominent post-translational regulator of protein tyrosine kinases (PTKs) that targets activated receptors for ubiquitination-mediated degradation. However, mutations within its E3 ubiquitin ligase activity rendering RING domain are often not sufficient to induc...
ORGANISM(S): Homo sapiens (Human) 
2021-02-26 | PXD011369 | Pride
On-beads digestion. Rtks Ubiquitination Cbl Label-free quantitation Endosomal trafficking 
ProteomicsNuclear-capture of endosomes drives depletion of nuclear G-actin to promote SRF/MRTF gene expression and cancer cell invasiveness (part 2: Surface and Nuclear Proteomes)
Signals are relayed from receptor tyrosine kinases (RTKs) at the cell surface to effector systems in the cytoplasm and nucleus, and coordination of this process is important for the execution of migratory phenotypes, such as cell scattering and invasion. The endosomal system influences how RTK sign...
ORGANISM(S): Homo sapiens (Human) 
2021-09-28 | PXD027268 | Pride
Invasiveness Serum-response factor (srf) Cell:cell repulsion Epha2 Heptocyte growth factor (hgf) Rab17 Surface and nuclear proteome Actin polymerisation Myocardin-related transcription factor (mrtf) Nuclear g-actin Nuclear import Pancreatic adenocarcinoma (pdac) 
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