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ProteomicsPhosphorylation of Primpol for repriming actiivity
SILAC-IP and mass spectrometric analysis of Primpol to determine phosphorylaton of a specific serine residue
ORGANISM(S): Homo sapiens (Human) 
2021-12-27 | PXD027918 | Pride
Repriming Dna repair Primpol Chk1 Dna tolerance 
ProteomicsAnalysis of fluorophore-labeled human cytochrome b5
Cytochrome b5 (b5) is a small accessory protein involved in several reactions. The interaction of b5 with its partner proteins, e.g., cytochrome P450 enzymes, has received much attention and has been the subject of numerous studies. In order to obtain further insights into protein-protein interactio...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD047758 | Pride
Cytochrome b5 Fluorophore Human Alexa 488 
ProteomicsMacrophage Responses to Helicobacter pylori
The purpose of this study was to examine macrophage proteomic changes induced by Helicobacter pylori. Macrophages utilized were the RAW 264.7 murine cell line. Macrophages were treated with H. pylori for 24 hours. The experimental design was a 4-plex isobaric tags for relative and absolute quantific...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD010082 | Pride
Proteomics Macrophages Immune response Helicobacter pylori 
ProteomicsWDR5 protein interactions at the WIN-site
The WIN site of WDR5 is a druggable pocket that impairs WDR5 protein function and carries therapeutic potential for treating cancer. This study evaluates the protein interactions affected by small molecule blockade of this surface on WDR5. Inhibited and uninhibited WDR5-containing complexes from HEK...
ORGANISM(S): Homo sapiens (Human) 
2021-01-25 | PXD019209 | Pride
Silac Wdr5 Immunoprecipitation Signaling Chromatin 
ProteomicsHelicobacter pylori infection dysregulates gastric proteome
The purpose of the study was to define gastric cell-specific proteomic changes, induced by H. pylori oncogenic strains, that are critical for initiation of the gastric carcinogenic cascade. Gastric cell scrapings were harvested from H. pylori-infected and uninfected animals for quantitative proteomi...
ORGANISM(S): Meriones unguiculatus 
2018-11-23 | PXD009583 | Pride
Gastric proteome Helicobacter pylor 
ProteomicsQuantitative Proteomics of the kidney AKT-mediated response to a potassium-deficient diet
Three groups of wild-type mice were fed either a normal diet, a potassium-deficient diet, or a potassium-deficient diet while being co-treated with the AKT inhibitor MK2206 (50 mg/kg). After treatment (4 days), animals were euthanized, and kidneys were snap-frozen in liquid nitrogen.
ORGANISM(S): Mus musculus (Mouse) 
2025-10-27 | PXD050107 | Pride
Kidney Proteomics Potassium deficiency Lc-ms/ms 
ProteomicsMDA-MB-231 blebbisome proteomics
Cells secrete a large variety of extracellular vesicles (EVs) to engage in cell-to-cell and cell-to-environment intercellular communication. EVs are functionally involved in many physiological and pathological processes by interacting with cells that facilitate transfer of proteins, lipids and genet...
ORGANISM(S): Homo sapiens (Human) 
2025-01-05 | PXD059407 | Pride
Ectosomes Microvesicles Large evs Small evs Proteomics Blebbisomes Lc-ms/ms 
MetabolomicsBacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway

The reverse transsulfuration pathway is the major route for the metabolism of sulfur-containing amino acids. The role of this metabolic pathway in macrophage response and function is unknown. We show that the enzyme cystathionine γ-lyase (CTH) is induced in macrophages infected with pathogenic ba...

2020-05-15 | MTBLS696 | MetaboLights
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