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MetabolomicsThe Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism
The overuse of antibiotics in animal agriculture and medicine has caused a series of potential threats to public health. Macleaya cordata is a medicinal plant species from the Papaveraceae family, providing a safe resource for the manufacture of antimicrobial feed additive for livestock. The active ...
2017-04-24 | MTBLS435 | MetaboLights
MetabolomicsMetabolome-based prediction of yield heterosis contributes to the breeding of elite rice
The improvement of breeding efficiencies for heterotic and climate-resilient crops can mitigate the food shortage crisis from overpopulation and climate change. Thus far, diverse molecular markers have been utilized for guiding field phenotypic selections, while the accurate predictions of complex h...
2019-12-10 | MTBLS742 | MetaboLights
ProteomicsProtein and Signaling Pathway Responses to rhIL-6 Intervention before Lobaplatin Treatment in Osteosarcoma Cells using LC-MS/MS
Lobaplatin is a third-generation platinum-based antineoplastic agent and is widely used for osteosarcoma treatment before and after tumor removal. However, treatment failure often results from lobaplatin drug resistance. In our study, we found that SaOS-2 and SOSP-9607 osteosarcoma cells became less...
ORGANISM(S): Homo sapiens (Human) 
2021-02-25 | PXD021564 | Pride
Human Lobaplatin Rhil-6 Osteosarcoma Liquid chromatography-tandem mass spectrometry 
ProteomicsDICAR+/- mouse heart Label free LC-MS
The level of ubiquitin protein of the heart of DICAR+/- compared with wild type
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD037732 | Pride
Heart Lc-msms 
ProteomicsAnalysis of the Byssus of Chinese Green Mussel proteomics by LC-MS/MS
Here, we integrated high-throughput transcriptome and proteome sequencing to construct a comprehensive protein database for the byssus of Chinese green mussel (Perna viridis), aiming at providing novel insights into the molecular mechanisms of byssal binding to heavy metals.
ORGANISM(S): Perna viridis 
2019-04-30 | PXD009183 | Pride
Proteomics Byssus Lc-msms 
ProteomicsConotoxin Exploitation from Conus betulinus
Employing Conus betulinus as a representative, we sequenced and assembled the first Conus genome. After integration of multi-omics data, we provide novel insights into the genetic central dogma of conotoxins, assuming a number ratio of ~1:1:10s for genes/transcripts/peptides.
ORGANISM(S): conus betulinus 
2021-09-08 | PXD014892 | Pride
Conus  genome  conotoxins  multi-omics  transcript  proteomics  peptide 
ProteomicsIdentification of a biomarker to predict doxorubicin/cisplatin chemotherapy efficacy for osteosarcoma patients by 4D data-independent acquisition (DIA) mass spectrometry with parallel reaction monitoring (PRM) verification
We analyzed the differentially expressed proteins in 37 resected tissue samples from osteosarcoma patients using paraffin- embedded specimens and 4D data-independent acquisition (DIA) quantitative mass spectrometry to investigate biomarkers for predicting the efficacy of doxorubicin/cisplatin chemot...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD051097 | Pride
Osteosarcoma  doxorubicin/cisplatin chemotherapy efficacy  data-independent acquisition (dia) mass spectrometry with parallel reaction monitoring (prm)  ctsg  neutrophil extracellular traps (nets) 
ProteomicsMST4 promotes MRC2 activity to drive osteosarcoma proliferation
Osteosarcoma is one of the most common types of orthopedic malignancies with an accelerated disease progression and poor prognosis.The purpose of this study was to further investigate the function of Serine/threonine protein kinase 4(MST4) in osteosarcoma and its underlying mechanisms. The expressio...
ORGANISM(S): Homo sapiens (Human) 
2026-10-26 | PXD034216 | Pride
Mrc2 Mst4 Osteosarcoma proliferation 
UnknownGenome of Crucihimalaya himalaica, a close relative of Arabidopsis, shows ecological adaptation to high altitude.
Not available
S-EPMC6452661 | biostudies-literature
UnknownEfficacy and Tolerability of First-Line Cetuximab Plus Leucovorin, Fluorouracil, and Oxaliplatin (FOLFOX-4) Versus FOLFOX-4 in Patients With RAS Wild-Type Metastatic Colorectal Cancer: The Open-Label, Randomized, Phase III TAILOR Trial.
Not available
S-EPMC6324088 | biostudies-literature
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