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ProteomicsCyclosporine A Modulates LSP1 Protein Levels in Human B Cells to Attenuate B Cell Migration at Low O2 Levels
Coordinated migration of B cells within and between secondary lymphoid tissues is required for robust antibody responses to infection or vaccination. Secondary lymphoid tissues normally expose B cells to a low O2 (hypoxic) environment. Recently, we have shown that human B cell migration is modulated...
ORGANISM(S): Homo sapiens (Human) 
2022-08-24 | PXD036167 | Pride
Chemotaxis Cxcr4 Human b cells Lsp1 
TranscriptomicsLeukocyte-Specific Protein1 Regulates T Cell Migration in Rheumatoid Arthritis
Copy number variations (CNVs) have been implicated in human diseases. However, it remains unclear how they affect immune dysfunction and autoimmune diseases, including rheumatoid arthritis (RA). Here, we identified a novel LSP1 deletion variant for RA susceptibility located in 11p15.5. We replicated...
ORGANISM(S): Mus musculus 
2016-06-01 | E-GEOD-75123 | biostudies-arrayexpress
ProteomicsTemporal regulation of Lsp1 O-GlcNAcylation and phosphorylation duringactivated Bcellsapoptosis
Here, we decipher the molecular mechanisms bridging B cell activation and apoptosis mediated by post-translational modification(PTM). We found that O-GlcNAcase inhibition enhances B cell activation and apoptosisinduced by B cell receptor (BCR)cross-linking. This proteome-scale analysis of the functi...
ORGANISM(S): Mus musculus (Mouse) 
2016-09-26 | PXD003788 | Pride
Phosphoproteome B cell O-glcnacylation Apoptosis 
UnknownIdentification and analysis of pathogenic nsSNPs in human LSP1 gene.
Not available
S-EPMC6859700 | biostudies-literature
UnknownLSP1-myosin1e bimolecular complex regulates focal adhesion dynamics and cell migration.
Not available
S-EPMC12315485 | biostudies-literature
UnknownDeficiency of leukocyte-specific protein 1 (LSP1) alleviates asthmatic inflammation in a mouse model.
Not available
S-EPMC9219131 | biostudies-literature
UnknownEisosomes are dynamic plasma membrane domains showing pil1-lsp1 heteroligomer binding equilibrium.
Not available
S-EPMC4390835 | biostudies-literature
UnknownCrucial role for the LSP1-myosin1e bimolecular complex in the regulation of Fcγ receptor-driven phagocytosis.
Not available
S-EPMC4436777 | biostudies-literature
UnknownQualification of LSP1-2111 as a Brain Penetrant Group III Metabotropic Glutamate Receptor Orthosteric Agonist.
Not available
S-EPMC4027608 | biostudies-literature
ProteomicsCryoEM architecture of a near-native stretch-sensitive membrane microdomain
Eisosomes, stress-sensitive membrane compartments in yeast, are scaffolded by the BAR-domain proteins Pil1 and Lsp1. We isolated near-native eisosomes as helical filaments of Pil1/Lsp1 lattice bound to plasma membrane lipids and solved their structure by helical reconstruction. From the same near-na...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-07-18 | PXD050326 | Pride
Membrane microdomain Eisosome Pil1 Lsp1 
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