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Proteomicsproteomic changes in aging rats treated with the cognitive enhancer CE-123
Aging rats with cognitive decline have been behaviourally evaluated and were divided into two groups, treated with CE-123, a dopamine transporter inhibitor, and vehicle. Memory-related brain areas were dissected and following sample preparation run on q-exactive from thermo fisher. Data handling and...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-16 | PXD022737 | Pride
Brain Cognitive enhancement Rat Aging 
ProteomicsCombined proteomic and transcriptomic analysis of Arion vulgaris
The Spanish slug, Arion vulgaris, is considered one of the hundred most invasive species in Central Europe. The lack of natural predators can refer to the potential toxicity of slugs. However, no transcriptomic or proteomic study has been done so far in Arion vulgaris. In this study, we present the ...
ORGANISM(S): Arion vulgaris 
2016-03-22 | PXD002078 | Pride
Slug 2-de Proteome Arion vulgaris Transcriptome Lc-ms/ms 
ProteomicsDifferential proteomics of the synaptosomal fraction from rat dentate gyrus identified the changes associated with aging-dependent cognitive decline
The study contained three groups of Sprague-Dawley male rats – two groups of aging animals (22-24 months) separated based on performance in spatial reference memory task; and the third, control group of young animals () not separated by behavioural testing. The synaptosome – enriched membrane fracti...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-08-19 | PXD013172 | Pride
Dentate gyrus Spatial reference memory Quantitative proteomics 
ProteomicsProteomics quantification of striatal fraction from DAT-KO and WT rats
The study aimed to find out quantitative changes at the protein level in the total membrane fraction enriched in synaptosomes and mitochondria upon the absence of the dopamine transporter in rat brain. Therefore, the brain of male rats (Wister Han) DAT-wildtype and DAT-knockout animals, were dissect...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-05-19 | PXD028157 | Pride
Lc-msms Dat-ko Knockout Striatum Rat Brain Dat Proteomics Dopamine transporter 
Proteomicsaplysia ganglion and memory formation
2 DE plus ion-trap mass spectrum to identify unknown proteins from ganglion of aplysia californica
ORGANISM(S): Aplysia californica (California sea hare) 
2010-01-03 | PRD000283 | Pride
ProteomicsAnalysis of mouse hippocampus membrane proteome by gel-based LC/MS
Mouse hippocampus membrane fractions were prepared using sucrose density gradient ultracentrifugation. Membrane proteins were solubilized using three different condition; 6-ACA/Triton X-100 or ProteoExtract Native Membrane Protein Extraction Kit (Calbiochem, Cat. No. 444810) or ProteoExtract Transme...
ORGANISM(S): Mus musculus (Mouse) 
2014-08-15 | PXD000311 | Pride
Mouse hippocampus Ltq orbitrap velos pro Membrane proteins Gel-based proteomics In-gel chymotrypsin/trypsin digestion 
ProteomicsQuantitative proteomic analysis of mouse hippocampus in the context of fear memory
Quantitative proteomic analysis was used to identify the proteins associated with a formation of fear memory in mice. The proteins from the hippocampal region were isolated from three groups of trained aminals representing aquisition, consolidation and retrieval of a contextual fear conditioning. Th...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-17 | PXD001639 | Pride
Contextual fear conditioning Fear memory Quantitative proteomic analysis Hippocampus 
ProteomicsA detailed proteomic analysis of plasma membrane from zebrafish brain
The brain plasma membrane proteome represents the major subsets of signaling proteins and promising drug targets though often understudied due to traditional experimental difficulties. Here we report a comprehensive dataset of the proteins identified in the highly enriched plasma membrane of zebrafi...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2018-07-05 | PXD004209 | Pride
Zebrafish brain Membrane proteome 
ProteomicsProteomic studies on the swimbladder of the European eel (Anguilla anguilla)
The swimbladder of fish is a vital organ that along with gas glands in the swimbladder wall enables key physiological functions including buoyance, diving and coping with different hydrostatic pressures. Specific intramural glands provide gas for regulating gas pressure in the swimming bladder. Tran...
ORGANISM(S): Anguilla anguilla 
2018-02-27 | PXD007850 | Pride
Neurotransmitter Receptor Transporter Anguilla anguilla Swimbladder European eel 
ProteomicsGel-free mass spectrometry analysis of Drosophila melanogaster heads
Here we describe a bottom-up approach to analyse an enriched membrane fraction from Drosophila melanogaster heads using multidimensional liquid chromatography (LC) coupled with tandem-mass spectrometry (MS/MS) that relies on a complete solubilisation and digestion of proteins. An enriched membrane f...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2015-07-27 | PXD001712 | Pride
Proteomics Mass spectrometry Heads Membrane proteins Drosophila melanogaster 
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