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ProteomicsKCMF1 links RAD6 to UBR4 and lysosome-mediated degradation
Raw mass spec. data files, converted peak lists and TPP results files for KCMF1 links RAD6 to UBR4 and lysosome-mediated degradation by Hong et. al, MCP 2014. RAD6 is a ubiquitin E2 protein with roles in a number of different biological processes. Here, using affinity purification coupled with mass ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-01-01 | MSV000078983 | MassIVE
ProteomicsLysosomal proteomics by affinity purification-mass spectrometry
The aims of this project is to establish a comprehensive proteomic map of the lysosomes using isolated lysosomes via affinity purification. Affinity-purified mitochondria was used as a control to demonstrate the organelle specificity. In this study, we identified several lipid transporters that are ...
ORGANISM(S): Homo sapiens (Human) 
2019-09-27 | PXD014733 | Pride
Mtorc1 Organelle Lysosome immunoprecipitation 
MetabolomicsShotgun lipidomics of HeLa whole-cell lysates and lysosomes following LLOMe treatment

Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach, we here identified the bridge-like lipid transport protein VPS13C/PARK23 as a key component of a...

2026-07-03 | MTBLS14737 | MetaboLights
ProteomicsA quantitative proteomic profile revealed the crucial roles of lysosome in the microbial infection
Lysosome played vital roles for both innate and adaptive immunity. It has been widely accepted that lysosome functioned more than a digestive organelle. However, it was still largely unknown for the proteome changes of lysosome on various microbes, and the understanding of lysosomal proteome from th...
ORGANISM(S): Homo sapiens (Human) 
2017-05-04 | PXD005748 | Pride
Proteomics Hypoxia Lysosome Monocyte 
ProteomicsFGF signaling modulates lysosome biogenesis in chondrocytes via the Mannose Phosphate Receptor pathway
The mannose-6-phosphate (M6P) pathway is critical for lysosome biogenesis, facilitating the trafficking of hydrolases to lysosomes to ensure cellular degradative capacity [1], [2]. Fibroblast Growth Factor (FGF) signaling, a key regulator of skeletogenesis [3], has been linked to the autophagy-lysos...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-08-25 | PXD063036 | Pride
Chondrocytes Lysosome Fgf 
ProteomicsFGF signaling modulates lysosome biogenesis in chondrocytes via the Mannose Phosphate Receptor pathway
The mannose-6-phosphate (M6P) pathway is critical for lysosome biogenesis, facilitating the trafficking of hydrolases to lysosomes to ensure cellular degradative capacity [1], [2]. Fibroblast Growth Factor (FGF) signaling, a key regulator of skeletogenesis [3], has been linked to the autophagy-lysos...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-08-25 | PXD063031 | Pride
Chondrocytes Lysosome Fgf 
ProteomicsFGF signaling modulates lysosome biogenesis in chondrocytes via the Mannose Phosphate Receptor pathway
The mannose-6-phosphate (M6P) pathway is critical for lysosome biogenesis, facilitating the trafficking of hydrolases to lysosomes to ensure cellular degradative capacity [1], [2]. Fibroblast Growth Factor (FGF) signaling, a key regulator of skeletogenesis [3], has been linked to the autophagy-lysos...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-08-25 | PXD063029 | Pride
Lysosome Fgf Chordrocytes 
UnknownLysosome transporter purification and reconstitution identifies Ypq1 pH-gated lysine transport and regulation.
Not available
S-EPMC10081341 | biostudies-literature
ProteomicsRUFY3 links Arl8b and JIP4-Dynein complex to regulate lysosome size and positioning
The whole-cell scale spatial organization of lysosomes is regulated by their bidirectional motility on microtubule tracks. Small GTP-binding (G) protein, Arl8b, stimulates the anterograde transport of lysosomes by recruiting adaptor protein SKIP (also known as PLEKHM2), which in turn couples the mic...
ORGANISM(S): Homo sapiens (Human) 
2022-03-23 | PXD027010 | Pride
Arl8b Lysosome Small gtpase Dynein Microtubule 
ProteomicsCharacterization of a novel membrane complex required for docking and regulated exocytosis of lysosome-related organelles in Tetrahymena thermophila
In the ciliate Tetrahymena thermophila, lysosome-related organelles called mucocysts accumulate at the cell periphery where they secrete their contents in response to extracellular events, a phenomenon termed regulated exocytosis. A forward genetic approach uncovered MDL1 (Mucocyst Discharge with a ...
ORGANISM(S): Tetrahymena thermophila CU428 
2022-04-06 | PXD028372 | Pride
Exocytosis Mucocysts Ciliate Tetrahymena Lysosome Mdl1 
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