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ProteomicsLysyl Oxidases are Necessary for Myometrial Contractility and On-Time Parturition in Mice
The extracellular matrix (ECM) plays a pivotal role in the maintenance of tissue mechanical homeostasis. Collagens and elastic fibers are the most predominant fibrous ECM proteins providing tissue mechanical function through covalent cross-linking, which is mediated by the lysyl oxidase family of en...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-18 | PXD055537 | Pride
Lysyl oxidase Pregnancy Extracellular matrix Myometrium Parturition 
GenomicsTranscriptome analysis of Y79 retinoblastoma cells upon Lysyl oxidase propeptide (LOX-PP) overexpression
Transcriptome analysis of Y79 retinoblastoma cells upon Lysyl oxidase propeptide (LOX-PP) overexpression
PRJNA489199 | ENA
GenomicsA First-in-Class Pan-Lysyl Oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer
A First-in-Class Pan-Lysyl Oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer
PRJNA775961 | ENA
TranscriptomicsA First-in-Class Pan-Lysyl Oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer
The lysyl oxidase family represents a promising target in stromal targeting of solid tumours due to the importance of this family in cross-linking and stabilising fibrillar collagens, and its known role in tumour desmoplasia. Using small-molecule drug design approaches, we generated and validated PX...
ORGANISM(S): Mus musculus 
2023-05-18 | GSE186748 | GEO
TranscriptomicsTranscriptome analysis of Y79 retinoblastoma cells upon Lysyl oxidase propeptide (LOX-PP) overexpression
Lysyl oxidase (LOX) is an copper dependent amine oxidase enzyme involved in cross linking of collagens and elastins. Lysyl oxidase propeptide (LOX-PP) is 18 kDa region cleaved during maturation of LOX and its anti-tumorigenic role were studied in various cancers. The effect of LOX-PP overexpression ...
ORGANISM(S): Homo sapiens 
2019-09-01 | GSE119413 | GEO
TranscriptomicsGATA3 Reprograms Basal Breast Cancer Cells towards a Luminal Subtype and Inhibits Metastases through Suppression of Lysyl Oxidase
The transcription factor GATA3 is essential for luminal cell differentiation during mammary gland development and critical for formation of the luminal subtypes of breast cancer. Ectopic expression of GATA3 promoted global alterations of the transcriptome of basal triple-negative breast cancer cells...
ORGANISM(S): Homo sapiens 
2011-08-31 | E-GEOD-24249 | biostudies-arrayexpress
GenomicsLysyl oxidase inhibition disrupts mitochondrial homeostasis to create vulnerability to ferroptosis in TNBC
Lysyl oxidase inhibition disrupts mitochondrial homeostasis to create vulnerability to ferroptosis in TNBC
PRJNA1374186 | ENA
ProteomicsMDA-MB-231 Breast Cancer Bone Tropic vs Parental Hypoxic Secretome Analysis
The project profiled the expression patterns in hypoxia induced secretomes between MDA-MB-231 parental and MDA-MB-231 Bone Tropic (BT) breast cancer cell lines which have been previously generated by Massague and colleagues (Kang et al. Cancer Cell 2003).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080797 | MassIVE
TranscriptomicsLysyl oxidase-like 2 (LOXL2) a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas
Basal-like breast carcinoma is characterized by the expression of basal/myoepithelial markers, undifferentiated phenotype, highly aggressive behaviour and a frequent triple negative status (ESR-, PR-, Her2neu-). We have previously shown that epithelial-mesenchymal transition (EMT) occurs in basal-li...
ORGANISM(S): Homo sapiens 
2011-10-20 | E-GEOD-29581 | biostudies-arrayexpress
ProteomicsLysyl Oxidase Mediated Collagen Cross-linking in Pancreatic Cancer
Bottom up proteomics, cross-linked amino acid analysis, and cross-linked peptide analysis were performed on eight PDAC tumor samples and paired adjacent non-tumor samples.
ORGANISM(S): Homo sapiens (Human) 
2025-08-28 | PXD050833 | Pride
Collagen Lysyl hydroxylase Xaaa Lysyl oxidase N-telo peptide Plod Lox Cross-linked peptide Ntx Pdac 
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