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ProteomicsExploration on survived mice after sepsis and proteomic analy-sis on LPS-activated macrophages supports the regulation of sepsis hyper-inflammation by intravenous immunoglobulin
Because the immune regulation in survivor after sepsis (an immune dysregulation from severe infection) might be applied for treatment, survivors and moribund mice after cecal liga-tion and puncture (CLP) and in vitro experiments on macrophages were explored. Most of the parameters in survivors (5-da...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-22 | PXD027471 | Pride
Sepsis  clp  macrophages  proteomic analysis  ivig 
ProteomicsDeciphering the proteome of naturally released extracellular vesicles from Leptospira interrogans serovar Pomona in response to temperature and osmotic stresses
The biogenesis and functions of Leptospira's extracellular vesicles (EVs) remain unclear. The study aimed to characterize EVs that were naturally released from intact leptospires during in vitro culture, as well as under conditions mimicking the host environment during infection, including temperatu...
ORGANISM(S): Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 
2024-01-26 | PXD042648 | Pride
Quantitative proteomics Extracellular vesicle Leptospirosis Osmotic stress Leptospira 
ProteomicsThe regulatory roles of Ezh2 in response to lipopolysaccharide (LPS) in macrophages and mice with conditional Ezh2 deletion with LysM-Cre system
The responses of macrophages to lipopolysaccharide (LPS) might determine the direction of clinical manifestations of sepsis, which is the immune response against severe infection. Meanwhile, the enhancer of zeste homologue 2 (Ezh2), a histone lysine methyltransferase of epigenetic regulation, might ...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD041265 | Pride
Lipopolysaccharide Macrophage Epigenetics Ezh2 Sepsis 
ProteomicsChlorhexidine promotes psl in Pseudomonas aeruginosa that enhances cell aggregation with preserved pathogenicity demonstrates an adaptation against antiseptic
Because Pseudomonas aeruginosa is a common pathogen that frequently contacts with Chlorhexidine digluconate (a regular antiseptic), then adaptations against Chlorhexidine were tested. In com-parison with the parent strain, the Chlorhexidine-adapted strain formed smaller colonies with the downregulat...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD034530 | Pride
Pseudomonas aeruginosa  chlorhexidine digluconate  chlorhexidine  cross-resistance  biofilm  psl  cell aggregate  persistence  wound infection 
ProteomicsCoexistence of Klebsiella pneumonia biofilms with Candida albicans in an acute pneumonia
Coexistence of polymicrobial organisms acted as biofilm communities has become more and more prominent that these interactions lead to an increased resistance against host immune responses and antimicrobial agents, especially bacterial-fungal interactions. Klebsiella pneumoniae and Candida albicans ...
ORGANISM(S): Candida albicans (Yeast) 
2025-05-13 | PXD050494 | Pride
Klebsiella pneumonia Pneumonia Biofilm formation Candida albicans Neutrophil extracellular traps 
ProteomicsEffects of Elaeagnus latifolia extract on anti-inflammation in LPS-induced macrophages
Inflammation is the essential process for responding to pathogenic infections, cancer, autoimmune diseases, and other inflammatory diseases. Oxidative stress leads to inflammatory responses. This study aims to evaluate whether the polyphenols in the Elaeagnus latifolia (EL) fruit water extract ameli...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD046383 | Pride
Anti-inflammation Polyphenol Anti-oxidation Macrophages Elaeagnus latifolia 
ProteomicsThe architecture and pathogenesis of Pseudomonas-Candida biofilms in infections and their influence on the microenvironment
Interkingdom Pseudomonas-Candida biofilms is a human pathogen associated with acute and chronic infection. This study examine hoe their structural organization influences their in vivo microenvironment, which in turns affects the interaction of Pseudomonas-Candida biofilms with host immune responses...
ORGANISM(S): Candida albicans (Yeast) 
2022-10-13 | PXD034528 | Pride
Pseudompnas aeruginosa Interkingdom biofilms Pneumonia Candida albicans 
ProteomicsMass Spectrometry-Driven Epitope Mapping: Application of Diethylpyrocarbonate Covalent Labeling for the Immunotherapeutic Target Programmed Cell Death Protein 1
Monoclonal antibodies (mAbs) have transformed cancer immunotherapy, with anti-PD1 mAbs playing a pivotal role. This study introduces diethylpyrocarbonate covalent labeling-mass spectrometry (DEPC CL-MS) as a rapid and sensitive technique for epitope mapping of PD1, a critical target in mAb developme...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-26 | MSV000096536 | MassIVE
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