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MetabolomicsMulti-omics and biophysical phosphoproteomics uncover functional phosphorylation networks of BRAFV600E-driven signaling

Dysregulated kinase activity drives oncogenic signalling, perturbs cellular homeostasis, and promotes tumour progression. Despite major success in targeting kinases therapeutically, the downstream consequences of kinase inhibition and the mechanisms underlying drug resistance remain incompletely ...

2025-12-09 | MTBLS7390 | MetaboLights
ProteomicsAUTOMATED PHOSPHOPEPTIDE ENRICHMENT FROM MINUTE QUANTITIES OF FROZEN MALIGNANT MELANOMA TISSUE
To acquire a deeper understanding of malignant melanoma (MM), it is essential to study the proteome of patient tissues. In particular, phosphoproteomics of MM has become of significant importance because of the central role that phosphorylation plays in the development of MM. Investigating clinical ...
ORGANISM(S): Homo sapiens (Human) 
2018-11-23 | PXD011175 | Pride
Bravo assaymap Sensitivity Fe(iii)-imac. Malignant melanoma phosphoproteomics Phosphopeptide enrichment 
TranscriptomicsRNAseq of A375 melanoma cells and A375 with ARID1A KO in control conditions and treatment with trametinib, vemurafenib or combination
The experiment aimed to study mechanisms of melanoma drug resistance. ARID1A confers resistance to trametinib and therefore RNAseq was collected alongside other omics data for parental A375 likes, and A375 lines with ARID1A KO, in the presence of no drug, trametinib, vemurafenib or their combination
ORGANISM(S): Homo sapiens 
2025-02-18 | E-MTAB-14759 | biostudies-arrayexpress
ProteomicsThe Human Melanoma Proteome Atlas – Defining the Molecular Pathology & Complementing the Melanoma Transcriptome
This project is an initiative to map the protein levels in malignant melanoma tumor samples, focused on in-depth histopathology coupled to proteome characterization. The protein levels and localization from this project were determined for a broad spectrum of diverse, surgically isolated melanoma tu...
ORGANISM(S): Homo sapiens (Human) 
2021-07-16 | PXD026086 | Pride
Proteogenomics Histopathology Heterogeneity Braf Phosphorylation Driver mutations Metastatic malignant melanoma Sub-cellular localization Acetylation stoichiometry Post-translational-modification 
UnknownAutomated phosphopeptide enrichment from minute quantities of frozen malignant melanoma tissue.
Not available
S-EPMC6287822 | biostudies-literature
TranscriptomicsCharting the functional landscape of phosphorylation through biophysical and multi-omics integration
Dysregulated kinase activity drives oncogenic signalling, perturbs cellular homeostasis, and promotes tumour progression. Despite major success in targeting kinases therapeutically, the downstream consequences of kinase inhibition and the mechanisms underlying drug resistance remain incompletely und...
ORGANISM(S): Homo sapiens 
2026-01-01 | E-MTAB-16292 | biostudies-arrayexpress
ProteomicsSerine-threonine kinase TAO3 mediated trafficking of endosomes containing the invadopodia scaffold TKS5-alpha promotes cancer invasion and tumor growth
Invadopodia are actin-based proteolytic membrane protrusions required for invasive behavior and tumor growth. In this study, we used our high-content screening assay to identify kinases whose activity impacts invadopodia formation. Among the top hits selected for further analysis was TAO3, a STE20-l...
ORGANISM(S): Homo sapiens (Human) 
2021-01-29 | PXD023867 | Pride
Tks5-alpha Taok3 Tao3 Tmt data Invadopodia Endosomes Phosphoproteomics Ptm quantitation Orbitrap fusion 
OtherProteomics and phosphoproteomics analysis of melanoma BRAF
Data from ProteomeXchange, PXD ID: PXD000497. Experiment: Mix2, Replica2, file: OR6_121121_GM_NKI_WP_Mix2_Replica2_Fr19.mzml. From ProteomeXchange: {{i}} Proteomics and phosphosproteomics analysis of BRAF mutant cells. {{/i}}
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310005623 | GPMDB
Resource Reanalysis 
ProteomicsVariable Thresholds for Phosphorylation Targets of the ERK Signaling Pathway
Cell fates regulated by ERK/MAP kinases respond to different thresholds of signaling strength. In mammalian cells, conditions that activate ERK to submaximal levels are sufficient to sustain proliferation, survival and transformation, while stimuli that activate ERK to very high levels often lead t...
ORGANISM(S): Homo sapiens (Human) 
2026-02-25 | PXD071110 | Pride
ProteomicsVariable Thresholds for Phosphorylation Targets of the ERK Signaling Pathway
Cell fates regulated by ERK/MAP kinases respond to different thresholds of signaling strength. In mammalian cells, conditions that activate ERK to submaximal levels are sufficient to sustain proliferation, survival and transformation, while stimuli that activate ERK to very high levels often lead t...
ORGANISM(S): Homo sapiens (Human) 
2026-02-25 | PXD071061 | Pride
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