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ProteomicsMonobromobimane labelling in early- and late-passage primary human mesemchymal stem cells subjected to 2 hour heat shock
Monobromobimane (mBBr) labelling: mBBr labelling was carried out either immediately prior to 42°C, two hour heat shock, or immediately following heat shock. Medium was removed from culture flasks and cells were washed using PBS. Cells were then labelled by incubation at 37°C with 6 mL of 400 µM mBBr...
ORGANISM(S): Homo sapiens (Human) 
2021-06-15 | PXD025329 | Pride
Human senescent heat shock msc mesenchymal stem cell monobromobimane mbbr 
ProteomicsMouse skin technical replicate negative control
Multivariate regression modelling provides a statistically powerful means of quantifying the effects of a given treatment while compensating for sources of variation and noise, such as variability between human donors and the behaviour of different peptides during mass spectrometry. However, methods...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-12 | PXD012784 | Pride
Bayesenproteomics Mouse skin Negative control 
ProteomicsPNGase-F treated and untreated peptides from primary human mesenchymal stem cells for protein/PTM quant benchmarking
Multivariate regression modelling provides a statistically powerful means of quantifying the effects of a given treatment while compensating for sources of variation and noise, such as variability between human donors and the behaviour of different peptides during mass spectrometry. However, methods...
ORGANISM(S): Homo sapiens (Human) 
2019-03-12 | PXD012782 | Pride
Bayesenproteomics Pngase-f Mesenchymal stem cell 
ProteomicsSerial mixture of peptides from mouse skin and primary human mesenchymal stem cells for protein quant methods benchmarking
Multivariate regression modelling provides a statistically powerful means of quantifying the effects of a given treatment while compensating for sources of variation and noise, such as variability between human donors and the behaviour of different peptides during mass spectrometry. However, methods...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-03-12 | PXD012772 | Pride
Bayesenproteomics Msc Skin 
UnknownPeptide location fingerprinting reveals modification-associated biomarker candidates of ageing in human tissue proteomes.
Not available
S-EPMC8135079 | biostudies-literature
UnknownIntraoperative Remifentanil Infusion and Postoperative Pain Outcomes After Cardiac Surgery-Results from Secondary Analysis of a Randomized, Open-Label Clinical Trial.
Not available
S-EPMC9423078 | biostudies-literature
ProteomicsProteome changes to primary human MSCs subjected to high-intensity cyclic tensile strain (CTS) aligned to SUN2 overexpressing samples
Our current understanding of cellular mechano-signalling is based on static models, which do not replicate the dynamics of living tissues. Here, we examined the time-dependent response of primary human mesenchymal stem cells (hMSCs) to cyclic tensile strain (CTS). At low-intensity strain (1 hour, 4%...
ORGANISM(S): Homo sapiens (Human) 
2019-04-24 | PXD012873 | Pride
Msc Cts 
ProteomicsPrimary human mesenchymal stem cells subjected to 1 Hz cyclic tensile strain, with and without 24 hour recovery
Cells resident in tissues must be resilient to the physical demands of their surroundings. Our current understanding of cellular mechano-signalling is largely based on static systems, but these models do not reproduce the dynamic nature of living tissue. Here, we examined the time-resolved response ...
ORGANISM(S): Homo sapiens (Human) 
2019-04-24 | PXD013287 | Pride
Nuclear decoupling Msc Cts 
ProteomicsDoxycycline-induced SUN2 overexpression in Y-201 MSC cell line
Cells resident in tissues must be resilient to the physical demands of their surroundings. Our current understanding of cellular mechano-signalling is largely based on static systems, but these models do not reproduce the dynamic nature of living tissue. Here, we examined the time-resolved response ...
ORGANISM(S): Homo sapiens (Human) 
2019-04-24 | PXD012863 | Pride
Sun2 Msc Overexpression 
ProteomicsPrimary Human MSCs subjected to 1 hr intense cyclic tensile strain with/without 24 hr recovery
Cells resident in tissues must be resilient to the physical demands of their surroundings. Our current understanding of cellular mechano-signalling is largely based on static systems, but these models do not reproduce the dynamic nature of living tissue. Here, we examined the time-resolved response ...
ORGANISM(S): Homo sapiens (Human) 
2019-04-24 | PXD012949 | Pride
Strain Msc Flexcell 
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