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ProteomicsSerial mixture of peptides from mouse skin and primary human mesenchymal stem cells for protein quant methods benchmarking
Multivariate regression modelling provides a statistically powerful means of quantifying the effects of a given treatment while compensating for sources of variation and noise, such as variability between human donors and the behaviour of different peptides during mass spectrometry. However, methods...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-03-12 | PXD012772 | Pride
Bayesenproteomics Msc Skin 
ProteomicsMouse skin technical replicate negative control
Multivariate regression modelling provides a statistically powerful means of quantifying the effects of a given treatment while compensating for sources of variation and noise, such as variability between human donors and the behaviour of different peptides during mass spectrometry. However, methods...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-12 | PXD012784 | Pride
Bayesenproteomics Mouse skin Negative control 
ProteomicsPNGase-F treated and untreated peptides from primary human mesenchymal stem cells for protein/PTM quant benchmarking
Multivariate regression modelling provides a statistically powerful means of quantifying the effects of a given treatment while compensating for sources of variation and noise, such as variability between human donors and the behaviour of different peptides during mass spectrometry. However, methods...
ORGANISM(S): Homo sapiens (Human) 
2019-03-12 | PXD012782 | Pride
Bayesenproteomics Pngase-f Mesenchymal stem cell 
ProteomicsProteomics on formalin-fixed and stained laser-capure microdissected human lung sections
A broad range of tissues have been examined by microscopy following a process of formalin fixation, paraffin embedment, sectioning and staining. Haematoxylin and eosin (H&E) – which respectively stain nuclei blue and other cellular and stromal material pink – are routinely used for clinical diagnosi...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD014762 | Pride
Lung Human Laser-capture Dissection Spatial proteomics Fixed 
UnknownLaser capture microdissection coupled mass spectrometry (LCM-MS) for spatially resolved analysis of formalin-fixed and stained human lung tissues.
Not available
S-EPMC7302139 | biostudies-literature
ProteomicsSecreted proteins extracted (3M NaCl) from EP/LP MSCs grown on soft/stiff substrates for 8 days
Tissues are maintained by homeostatic feedback mechanisms in which cells can respond to, but also modify, the chemical and mechanical properties of the surrounding extracellular matrix (ECM). Mechano-sensitive mesenchymal stem cells (MSCs) resident in the marrow niche experience a diverse mechanical...
ORGANISM(S): Homo sapiens (Human) 
2022-10-10 | PXD013241 | Pride
Senescence Msc Ageing Stiffness 
ProteomicsIntracellular proteome (SDS/Na-DoC) extract from EP/LP MSCs grown on soft/stiff hydrogels for 4 days
Tissues are maintained by homeostatic feedback mechanisms in which cells can respond to, but also modify, the chemical and mechanical properties of the surrounding extracellular matrix (ECM). Mechano-sensitive mesenchymal stem cells (MSCs) resident in the marrow niche experience a diverse mechanical...
ORGANISM(S): Homo sapiens (Human) 
2022-10-10 | PXD013240 | Pride
Mscs Senescence Mechanotransduction Ageing 
ProteomicsMSCs on soft/stiff substrates treated with ROCK or myosin II inhibitors
Tissues are maintained by homeostatic feedback mechanisms in which cells can respond to, but also modify, the chemical and mechanical properties of the surrounding extracellular matrix (ECM). Mechano-sensitive mesenchymal stem cells (MSCs) resident in the marrow niche experience a diverse mechanical...
ORGANISM(S): Homo sapiens (Human) 
2022-10-12 | PXD013239 | Pride
Msc Mechanotransduction Contractility 
ProteomicsSpatially-targeted optical microproteomics timecourse of rat myocardial infarction
Myocardial infarction (MI) results from occlusion of blood supply to the heart muscle causing death of cardiac muscle cells. Following myocardial infarction (MI), scar formation acts to mechanically stabilise the injured heart to prevent rupture and death. While fibroblasts and macrophages are impli...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-10-31 | PXD034413 | Pride
Cardiac Heart Macrophage Cd68 Rat Sma Microproteomics Fibroblast Myocardial infarction 
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