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ProteomicsG-CSF reshapes the cytosolic PCNA scaffold and modulates glycolysis in neutrophils
The balance between neutrophil survival and apoptosis must be tightly regulated to avoid exaggerated inflammatory responses. Cytosolic proliferating cell nuclear antigen (PCNA) is involved in neutrophil survival and function, where it acts as a scaffold and associates with proteins involved in NADPH...
ORGANISM(S): Homo sapiens (Human) 
2024-02-15 | PXD043496 | Pride
Pcna Neutrophil Survival G-csf Glycolysis 
ProteomicsMetabolic flexibility and expression of CD98 define the low density neutrophils mobilised in response to G-CSF
Low density neutrophils (LDN) co-purify with mononuclear cells during density-gradient separation of peripheral blood. LDN are rarely detected in healthy individuals but appear in the peripheral blood (PB) of patients with inflammatory diseases, malignancies and in individuals treated with granulocy...
ORGANISM(S): Homo sapiens (Human) 
2022-12-19 | PXD023952 | Pride
Proteogenomics G-csf Neutrophils 
ProteomicsNuclear-capture of endosomes drives depletion of nuclear G-actin to promote SRF/MRTF gene expression and cancer cell invasiveness.
Signals are relayed from receptor tyrosine kinases (RTKs) at the cell surface to effector systems in the cytoplasm and nucleus, and coordination of this process is important for the execution of migratory phenotypes, such as cell scattering and invasion. The endosomal system influences how RTK sign...
ORGANISM(S): Homo sapiens (Human) 
2021-09-28 | PXD027217 | Pride
Invasiveness Serum-response factor (srf) Cell:cell repulsion Epha2 Heptocyte growth factor (hgf) Rab17 Actin polymerisation Myocardin-related transcription factor (mrtf) Nuclear g-actin Nuclear import Pancreatic adenocarcinoma (pdac) 
UnknownMechanism of the intrinsic arginine finger in heterotrimeric G proteins.
Not available
S-EPMC5167181 | biostudies-literature
ProteomicsProteomic identification of the GPER1 interactome
The G-protein coupled estrogen receptor GPER1 is thought to mediate rapid estrogen signaling at the membrane. Despite considerable efforts over the last years, its physiological ligand(s), interactors, and regulators are still very poorly understood. This is particularly problematic at a time when t...
ORGANISM(S): Homo sapiens (Human) 
2023-11-06 | PXD041943 | Pride
G-protein coupled estrogen receptor  membrane protein  estrogen signaling  protein-protein interactions  proximity labeling 
ProteomicsAn omics-based metabolic model of methane-driven denitrification by aerobic methanotrophic bacteria
Methylomonas denitrificans is the first characterized organism that couples methane oxidation to nitrate reduction in pure culture without a partner. The aim of this study is to develop a metabolic model of methane driven nitrate respiration using a multi-level omics approach. Samples of M. denitrif...
ORGANISM(S): Methylomonas denitrificans 
2025-09-17 | PXD004041 | Pride
Methane Denitrification Omics Hypoxic Methylomonas Respiration Methanotroph Nitrous oxide Nitrate 
UnknownA transplantable phosphorylation probe for direct assessment of G protein-coupled receptor activation.
Not available
S-EPMC3383726 | biostudies-literature
UnknownG-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands.
Not available
S-EPMC3087483 | biostudies-literature
UnknownThe association between dengue immunoglobulin G titres with previous clinical dengue infection and white cell counts in Cuban children: A population-based study.
Not available
S-EPMC6261577 | biostudies-literature
UnknownAttenuated G protein signaling and minimal receptor phosphorylation as a biochemical signature of low side-effect opioid analgesics.
Not available
S-EPMC9065038 | biostudies-literature
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