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UnknownSimultaneous engineering of an enzyme's entrance tunnel and active site: the case of monoamine oxidase MAO-N.
Not available
S-EPMC6099926 | biostudies-literature
UnknownA Tet/Q Hybrid System for Robust and Versatile Control of Transgene Expression in C. elegans.
Not available
S-EPMC6327101 | biostudies-literature
ProteomicsIdentification of ASC-interacting proteins
To explore the spatiotemporal regulation of ASC speck formation and inflammasome activation, we infected primary WT and Asc–/– bone marrow-derived macrophages (BMDMs) with the bacterium Francisella novicida to induce AIM2 inflammasome activation and then performed ASC IP-MS to identify proteins that...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-29 | PXD052497 | Pride
Asc Francisella novicida Inflammasome Bmdm Mouse 
ProteomicsIdentification of ASC-interacting proteins
To explore the spatiotemporal regulation of ASC speck formation and inflammasome activation, we treated primary WT and Asc–/– bone marrow-derived macrophages (BMDMs) with LPS (500 ng/ml) and ATP (5 mM) to activate NLRP3 inflammasome activation and then performed ASC IP-MS to identify proteins that i...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-29 | PXD054933 | Pride
Asc Mouse bmdm Lps and atp Nlrp3 inflammasome 
ProteomicsProximity Labeling and Genetic Screening Reveals the Role of DSG2/Siglec-9 Axis in Suppressing Macrophage Phagocytosis
In current study, we have established a combined strategy using proximity labeling and genetic screening to identify the cellular ligands of Siglec-9. Our use of proximity labeling using APEX2 fusion proteins followed by quantitative proteomics allowed us to efficiently label and enrich cell surface...
ORGANISM(S): Homo sapiens (Human) 
2024-12-23 | PXD051557 | Pride
Siglec-9 Apex2 Dsg2 Proximity label 
ProteomicsHRD1 IP-MS in WT and SEL1L deficiency HEK293T cells
To gain further insights into the role and importance of SEL1L in HRD1 ERAD, we performed unbiased proteomics LC-MS analyses to map SEL1L and HRD1 interactomes in WT and SEL1L-/-, WT and HRD1-/- HEK293T cells, respectively.
ORGANISM(S): Homo sapiens (Human) 
2024-01-10 | PXD043674 | Pride
Erad complex formation Sel1l-hrd1 erad Hek293t 
MetabolomicsThe Crosstalk between Microbiota and Metabolites in AP Mice Based on Metagenomics and Untargeted Metabolomics

BACKGROUND AND PURPOSE: The microbiota dysfunction aggravated the severity of acute pancreatitis (AP), but the relationship between microbiota dysfunction and metabolites alteration was not fully explained. This study aimed to explore the crosstalk between microbiota and metaboli...

2023-08-10 | MTBLS6831 | MetaboLights
UnknownReal-world Chinese herbal medicine for Parkinson's disease: a hospital-based retrospective analysis of electronic medical records.
Not available
S-EPMC11096516 | biostudies-literature
UnknownProanthocyanidin B2 Alleviates Cuprizone-Induced Demyelination by Regulating the Astrocytic xCT/GSH/GPX4 Axis.
Not available
S-EPMC12446574 | biostudies-literature
UnknownHigh-resolution metabolomic biomarkers for lung cancer diagnosis and prognosis.
Not available
S-EPMC8175557 | biostudies-literature
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