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TranscriptomicsA compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupy CBF-MYH11/RUNX1 target genes
Different mechanisms for CBF-MYH11 function in acute myeloid Leukemia (AML) with inv(16) have been proposed such as tethering of RUNX1 outside the nucleus, interference with transcription factor complex assembly and recruitment of histone deacetylases, all resulting in transcriptional repression of ...
ORGANISM(S): Homo sapiens 
2013-09-09 | E-GEOD-46044 | biostudies-arrayexpress
ProteomicsIdentification of global proteome changes upon DFP treatment of HeLa cells
We aimed to identify proteins that would be turned over upon DFP treatment, a small molecule that mimicks hypoxia treatment and which induces NIX/BNIP3 mitophagy. We aimed to identify which proteins are degraded upon 24 h DFP treatment and verified whether there was an enrichment of mitochondrial pr...
ORGANISM(S): Homo sapiens (Human) 
2025-01-30 | PXD060356 | Pride
Mitophagy Bnip3 Dfp Hypoxia Mitochondria Nix 
ProteomicsIdentification of global proteome changes upon rapalog-induced tethering of WIPI2 to the mitochondrial outer membrane in wild-type or NIX/BNIP3 DKO HeLa cells
We aimed to identify proteins that would be turned over upon artificial tethering of WIPI2 to the mitochondrial surface upon rapalog treatment, using the FIS1-FRB plus FKBP-GFP-WIPI2 tethering system. We had previously observed that this induces mitophagy based on flow cytometry analysis of the mt-m...
ORGANISM(S): Homo sapiens (Human) 
2025-01-30 | PXD060363 | Pride
Mitophagy Wipi2 Bnip3 Hypoxia Mitochondria Nix 
GenomicsCandida albicans induces monocyte training via epigenetic programming through a dectin 1-dependent pathway
Non-specific protective effects against reinfection have been described following infection with Candida albicans. Here we show that mice defective in functional T and B lymphocytes were protected against reinfection with C. albicans in a monocyte-dependent manner. C. albicans and beta glucans induc...
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-34260 | biostudies-arrayexpress
UnknownValidation of a radiosensitivity molecular signature in breast cancer.
Not available
S-EPMC3993974 | biostudies-literature
TranscriptomicsA high-resolution transcriptome map of Ectocarpus siliculosus
Brown algae (Phaeophyceae) are complex photosynthetic organisms with a very different evolutionary history to green plants, to which they are only distantly related. These seaweeds are the dominant species in rocky coastal ecosystems and they exhibit many interesting adaptations to these, often hars...
ORGANISM(S): Ectocarpus siliculosus 
2010-04-07 | E-GEOD-19912 | biostudies-arrayexpress
ProteomicsFunctional characteristics of neonatal rat beta cells With distinct markers
Neonatal beta cells are considered developmentally immature and hence less glucose-responsive. To study the acquisition of mature glucose-responsiveness, we compared glucose-regulated redox state, insulin synthesis and secretion of beta cells purified from neonatal or 10-weeks old rats to their tran...
ORGANISM(S): Rattus norvegicus (Rat) 
2014-12-12 | PXD001577 | Pride
Lcmse Rat Diabetes Label free quantitation Pancreas 
UnknownComparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control.
Not available
S-EPMC3341644 | biostudies-literature
UnknownCerebrospinal fluid is a significant fluid source for anoxic cerebral oedema.
Not available
S-EPMC9014743 | biostudies-literature
TranscriptomicsDll1 marks early secretory progenitors in gut crypts that can revert to stem cells upon tissue damage
The introduction of GFP into the Dll1 locus has made it possible to isolate and study primary intestinal Dll1 positive cells, which constitute the secretory cell precursors of the intestine. Applying DNA array technology, we profiled the RNA changes of FACS-sorted Dll1_high/CD24_low, Dll1_high/CD24_...
ORGANISM(S): Mus musculus 
2012-09-27 | E-GEOD-39915 | biostudies-arrayexpress
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