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UnknownThe USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia.
Not available
S-EPMC8169803 | biostudies-literature
ProteomicsThe USP7-TRIM27 axis as part of non-canonical PRC1.1 is a druggable target in leukemia
In an attempt to unravel the functionality and targettability of the non-canonical PRC1.1 Polycomb complex in human leukemogenesis, we dissected the subunit composition of the PRC1.1 complex and show that USP7 and TRIM27 are integral components. USP7 interactome analyses show that PRC1.1 is the pred...
ORGANISM(S): Homo sapiens (Human) 
2021-06-14 | PXD018365 | Pride
Trim27 Leukemia Prc1.1 Polycomb Usp7 
ProteomicsPathogenesis of dominant-negative mutant GFI1B and associated proteomic abnormalities in megakaryocytes and platelets
Dominant-negative mutations in transcription factor Growth Factor Independence-1B (GFI1B) cause a bleeding disorder characterized by a plethora of megakaryocyte and platelet abnormalities. The deregulated molecular mechanisms and pathways are unknown. Here we show that normal and mutant GFI1B inter...
ORGANISM(S): Homo sapiens (Human) 
2019-01-25 | PXD009020 | Pride
Megakaryocytes Lsd1 Bleeding disorder Lc-ms Proteomics Platelet Gfi1b 
UnknownChromatin activation as a unifying principle underlying pathogenic mechanisms in multiple myeloma.
Not available
S-EPMC7545147 | biostudies-literature
UnknownDynamics of Transcription Regulation in Human Bone Marrow Myeloid Differentiation to Mature Blood Neutrophils.
Not available
S-EPMC6326331 | biostudies-literature
UnknownCirculating endothelial signatures correlate with worse outcomes in COVID-19, respiratory failure and ARDS.
Not available
S-EPMC12522733 | biostudies-literature
UnknownMulti-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients.
Not available
S-EPMC10203880 | biostudies-literature
GenomicsBP_August_2016_RNA-Seq_hematopoietic_multipotent_progenitor_cell_on_GRCh38 - samples
RNA-Seq data for 3 hematopoietic multipotent progenitor cell sample(s). 9 run(s), 3 experiment(s), 3 analysis(s) on human genome GRCh38. Part of BLUEPRINT release August 2016. Analysis documentation available at http://ftp.ebi.ac.uk/pub/databases/blueprint/releases/20160816/homo_sapiens/README_rnase...
EGAD00001002363 | EGA
GenomicsBP_January_2015_RNA-Seq_CD34-negative,_CD41-positive,_CD42-positive_megakaryocyte_cell - samples
RNA-Seq data for 5 CD34-negative, CD41-positive, CD42-positive megakaryocyte cell sample(s). 23 run(s), 5 experiment(s), 5 alignment(s). Part of BLUEPRINT release January 2015. Analysis documentation available at http://ftp.ebi.ac.uk/pub/databases/blueprint/releases/20140811/homo_sapiens/README_rnas...
EGAD00001001165 | EGA
GenomicsBP_August_2015_RNA-Seq_granulocyte_monocyte_progenitor_cell_on_GRCh38 - samples
RNA-Seq data for 3 granulocyte monocyte progenitor cell sample(s). 3 run(s), 3 experiment(s), 3 alignment(s) on human genome GRCh38. Part of BLUEPRINT release August 2015. Analysis documentation available at http://ftp.ebi.ac.uk/pub/databases/blueprint/releases/20150820/homo_sapiens/README_rnaseq_an...
EGAD00001001501 | EGA
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