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TranscriptomicsStem cell factor programs the mast cell activation phenotype
Mast cells, activated by antigen via the high affinity receptor for IgE (FcεRI), release an array of pro-inflammatory mediators that contribute to allergic disorders such as asthma and anaphylaxis. The KIT ligand, stem cell factor (SCF), is critical for mast cell expansion, differentiation and survi...
ORGANISM(S): Mus musculus 
2012-05-01 | E-GEOD-35332 | biostudies-arrayexpress
ProteomicsMast cell intracellular traps (MIT) release neutrophil effector proteins during degranulation and nexocytosis
Degranulating mast cells (MCs) release inflammatory mediators (proteins, lipids, small molecules), including chemokines and chemoattractants, which recruit other immune cells in tissues. Neutrophils can initiate self-amplifying swarming responses via intercellular communication through the lipid leu...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-18 | PXD044140 | Pride
Proteomics of secreted proteins Neutrophiles Mast cells Secretome Entosis Mast cell intracellular traps 
ProteomicsCell-intrinsic steroidogenesis regulates mast cell function
Steroid hormones are well known regulators of mast cell function, but whether mast cells themselves produce steroids de novo and influences their effector function has remained unknown. Here, we show that mast cells constitutively express the steroidogenic enzyme Cyp11a1 and produce pregnenolone. Cy...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-04 | PXD079140 | Pride
Mast cell degranulation Cyp11a1 Mast cell Steroid-signalling   anaphylaxis Steroidogenesis Pregnenolone 
ProteomicsCell-intrinsic steroidogenesis regulates mast cell function
Steroid hormones are well known regulators of mast cell function, but whether mast cells themselves produce steroids de novo and influences their effector function has remained unknown. Here, we show that mast cells constitutively express the steroidogenic enzyme Cyp11a1 and produce pregnenolone. Cy...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-04 | PXD079414 | Pride
Mast cell degranulation Cyp11a1 Mast cell Steroid-signalling   anaphylaxis Steroidogenesis Pregnenolone 
TranscriptomicsTranscription profiling of rat mast cells from diabetic prone and diabetic resistant strains
Abstract; Human type 1 diabetes mellitus (T1DM) arises through autoimmune destruction of pancreatic β cells and is modeled in many respects by the lymphopenic and spontaneously diabetic BioBreeding (BB) DRlyp/lyp rat. Previously, pre-onset expression profiling of whole DRlyp/lyp pancreatic lymph...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-4990 | biostudies-arrayexpress
TranscriptomicsMast cell expression data from murine aryl hydrocarbon receptor (AhR) null, AhR_d and normal control mice
We found that AhR, a unique chemical sensor, is critical in controlling mast cell differentiation, growth and function in vitro and in vivo. This study seeks to further the understanding of the mechanisms of how AhR control mast cell homeostasis. Three different batches of bone marrow derived mast c...
ORGANISM(S): Mus musculus 
2013-04-01 | E-GEOD-44715 | biostudies-arrayexpress
ProteomicsTomosyn is upregulated by IgE and functions as a PKC-regulated fusion clamp in mast cell degranulation
The regulation of soluble N ethylmaleimide sensitive factor attachment receptor (SNARE) mediated membrane fusion by upstream signaling events is poorly understood. Here we show that the SNARE binding protein tomosyn-1 negatively regulates type I IgE Fc receptor (FcRI) induced degranulation of mast c...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-04 | PXD010047 | Pride
Q-exactive plus Immunoprepicipitations Mast cells Mouse Phosphorylations Ige fc receptor 
ProteomicsBone marrow-derived mast cells +- IL-33 48h
Mast cells are tissue resident granulocytes which are most abundant at the interface between tissues and the external environment, such as around blood vessels, in the skin or mucosal surfaces in the lungs and gut. Pathologically they are involved in allergic reactions and anaphylaxis, however they ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD033759 | Pride
Granulocyte Mouse Lc-ms Mast cell Il-33 
TranscriptomicsMurine bone marrow-derived mast cells (BMMCs) transduced with pAPM lentiviruses overexpressing miR-221 vs control overexpressing miR-221m.
Bone marrow-derived mast cells were derived from three different female C57Bl/6 mice of similar age. Cells were transduced with pAPM lentiviruses either overexpressing microRNA-221 or a non functional microRNA-221 mutant, termed miR-221m, where four point-mutations were introduced in the seed sequen...
ORGANISM(S): Mus musculus 
2011-11-23 | E-GEOD-24462 | biostudies-arrayexpress
ProteomicsSynovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis
Mast cells are phenotypically and functionally highly heterogeneous, and their state is possibly controlled by their local microenvironment. Therefore, concrete analyses are needed to understand whether mast cells act as powerful motivators or dispensable bystanders in specific diseases. Here, we ev...
ORGANISM(S): Homo sapiens (Human) 
2024-01-07 | PXD038584 | Pride
Ra • synovial microenvironment • mast cells • mrgprx2 
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