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MetabolomicsNutrient environment drives strain-specific remodelling of Escherichia coli lipidomes
Background/Objectives: Escherichia coli causes more than 2.8 million infections annually and is widely used as a model organism. Despite its importance, strain-level and handling differences in E. coli lipidomes remain poorly defined. Lipid composition can reveal membrane organization, metabolic sta...
2026-09-23 | MTBLS14565 | MetaboLights
TranscriptomicsTranscription profiling of human alveolar macrophages from phenotypically normal smokers compared to non-smokers to identify new genes linking to early events in the molecular pathogenesis of COPD
Cigarette smoking is the leading cause of the respiratory diseases collectively known as chronic obstructive pulmonary disease (COPD). While the pathogenesis of COPD is complex, there is abundant evidence that alveolar macrophages (AM) play an important role. Based on the concept that COPD is a slow...
ORGANISM(S): Homo sapiens 
2007-09-06 | E-GEOD-3212 | biostudies-arrayexpress
ProteomicsNew Insights into the impact of Human Papillomavirus on Oral Cancer in Young Patients: Proteomic Approach Reveals a Novel Role for S100A8
Human Papillomavirus (HPV) infection has been recently linked to a subset of cancers affecting the oral cavity. However, the molecular mechanisms underlying HPV-driven oral squamous cell carcinoma (OSCC) onset and/ progression are poorly understood. Methods: We perform a MS-based proteomic profiling...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD041856 | Pride
New insights into the impact of human papillomavirus on oral cancer in young patients: proteomic approach reveals a novel role for s100a8 
UnknownThe Cognition and Affect after Stroke - a Prospective Evaluation of Risks (CASPER) study: rationale and design.
Not available
S-EPMC4866410 | biostudies-literature
ProteomicsConnecting multiple microenvironment proteomes uncovers the biology in head and neck cancer
The poor prognosis of head and neck cancer (HNC) is associated with metastasis within the lymph nodes (LNs). Herein, the proteome of 140 multisite samples from a 59-HNC patient cohort, including primary and matched LN-negative or -positive tissues, saliva, and blood cells, reveals insights into the ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-21 | PXD027780 | Pride
Machine learning Head and neck squamous cell carcinoma Buffy coat Saliva Mouth neoplasms Proteomics Lymph node metastasis Prognosis Immune system Biomarkers 
UnknownMobilization of CD34(+)CD38(-) hematopoietic stem cells after priming in acute myeloid leukemia.
Not available
S-EPMC3812523 | biostudies-literature
UnknownImaging markers associated with the development of post-stroke depression and apathy: Results of the Cognition and Affect after Stroke - a Prospective Evaluation of Risks study.
Not available
S-EPMC7092734 | biostudies-literature
ProteomicsNew Insights into the impact of Human Papillomavirus on Oral Cancer in Young Patients: Proteomic Approach Reveals a Novel Role for S100A8
Human Papillomavirus (HPV) infection has been recently linked to a subset of cancers affecting the oral cavity. However, the molecular mechanisms underlying HPV-driven oral squamous cell carcinoma (OSCC) onset and/ progression are poorly understood. Methods: We perform a MS-based proteomic profiling...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-10-06 | MSV000099405 | MassIVE
ProteomicsReductionist approach using primary and metastatic cell-derived extracellular vesicles prospect proteins associated with oral cancer prognosis
Oral squamous cell carcinoma (OSCC) shows high mortality rates that are largely associated with the presence of lymph node metastasis. However, the molecular mechanisms that drive OSCC metastasis are unknown. Here, we used a reductionist approach mapping the proteomic, miRNA, metabolomic and lipidom...
ORGANISM(S): Homo sapiens (Human) 
2021-07-19 | PXD019216 | Pride
Metabolomics Mirna Multi-omics approach Lipidomics Lymph node metastasis Extracellular vesicles Oral cancer squamous cell carcinoma Proteomics Prognosis 
ProteomicsADAM17 cytoplasmic domain modulates Thioredoxin-1 conformation and activity
We have demonstrated that site-directed mutagenesis in ADAM17 (ADAM17cytoF730A) also disrupts the interacting interface with Trx-1, resulting in a decrease of Trx-1 reductive capacity and activity. One of the mechanisms that explain this effect might be that ADAM17cyto favors Trx-1 monomerization st...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD015431 | Pride
Adam17 Thioredoxin-1 Mass spectrometry Redox signaling. Dimerization Iodotmt 
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