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Human primary granulosa cells (GCs) derived from women, undergoing oocyte retrieval, can be cultured and are a cellular model for the study of human ovarian functions. In vitro they change rapidly, resembling initially cells of the preovulatory follicle and then cells of the corpus luteum. They are ...
ORGANISM(S): Homo sapiens (Human) 
2021-07-28 | PXD025632 | Pride
In the ovary, proliferation and differentiation of granulosa cells (GCs) drive the growth of follicles. This is, in part, dependent on gonadotropins. Our immunohistochemical studies provided hints of mitochondrial biogenesis and intracellular redistribution in GCs of growing follicles. A cellular mo...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD032160 | Pride
The goal of the study was to evaluate consequences of Filamin A deficiency in granulosa cell tumor-derived KGN cells. Therefore, proteomes of WT and Filamin A deficient KGN cells were quantitatively compared using LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2026-05-22 | PXD064136 | Pride
Human granulosa cells (GCs) give rise to granulosa cell tumors (GCTs), in which a hypoxic situation can be assumed. KGN cells are a widely used cellular model for both tumorous and normal human GCs. In this study, we evaluated consequences of hypoxic (1% O2) versus atmospheric conditions on KGNs for...
ORGANISM(S): Homo sapiens (Human) 
2025-11-19 | PXD056016 | Pride
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