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ProteomicsComparative Membrane Proteomics Analyses of Breast Cancer Cell Lines to Understand the Molecular Mechanism of Breast Cancer Brain Metastasis
Breast cancer is the leading type of cancer in women. Breast cancer brain metastasis is considered as an essential issue in breast cancer patients. Membrane proteins play important roles in breast cancer brain metastasis that contributes to the cell adhesion and penetration of blood-brain barrier. T...
ORGANISM(S): Homo sapiens (Human) 
2017-05-23 | PXD005719 | Pride
Proteomics Breast cancer brain metastasis Membrane enrichment Differential expression analysis Lc-ms/ms 
ProteomicsPRM-MS quantitative analysis of isomeric N-glycopeptides derived from human serum haptoglobin of patients with cirrhosis and hepatocellular carcinoma
Comprehensive LC-PRM-MS approach where a targeted parallel reaction monitoring (PRM) strategy was coupled to a powerful LC system to study the microheterogeneity of serum haptoglobin (Hp) extracted from 15 patients with cirrhosis and 15 with hepatocellular carcinoma (HCC).
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD023719 | Pride
N-glycopeptides Prm Hepatocellular carcinoma (hcc) Haptoglobin Cirrhosis 
ProteomicsComparative Transcriptomics and Proteomics of Cancer Cell Lines Cultivated by Physiological and Commercial Media
Aiming to reduce the gap between in vitro and in vivo environment, a complex culture medium, Plasmax, was introduced recently, which includes nutrients and metabolites with concentrations normally found in human plasma. Herein, to study the influence of this medium on cellular behaviors, we utilized...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD033841 | Pride
Culture media Proteomics Transcriptomics Cancer cell line Differential expression analysis Lc-ms/ms 
ProteomicsEnhanced Quantitative LC-MS/MS Analysis of N-linked Glycans Derived from Glycoproteins Using Sodium Deoxycholate Detergent
Protein glycosylation is a common protein post-translational modification (PTM) in living organisms and has been shown to associate with multiple diseases, and thus may potentially be a biomarker of such diseases. Efficient protein/glycoprotein extraction is a key step in the preparation of N-glycan...
ORGANISM(S): Homo sapiens (Human) 
2018-05-16 | PXD008687 | Pride
Acidic labile detergent Detergent removal Lc-ms/ms sample preparation N-glycomics Sodium deoxycholate 
ProteomicsHILIC and ERLIC Enrichment of Glycopeptides Derived from Breast and Brain Cancer Cells
Aberrant glycosylation has been linked to many different cancer types. The blood brain barrier (BBB) is a region of the brain that regulates the entrance of ions, diseases, toxins, etc. However in breast cancer metastasis, the BBB fails to prevent the crossing of the cancer cells into the brain. Her...
ORGANISM(S): Homo sapiens (Human) 
2019-02-27 | PXD004361 | Pride
Hilic enrichment Glycoproteomics Erlic enrichment Mass spectrometry Blood brain barrier Cancer cell lines N-linked glycosylation 
ProteomicsSpike Glycoprotein S1 Site-specific O-glycosylation: Systematic and Comparative Analysis from Eleven Variants of SARS CoV-2
In this study, we provide a comprehensive characterization of O-glycosylation in eleven variants of SARS-CoV-2 S1 subunit recombinantly expressed in HEK293 cells.
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD041282 | Pride
Mutations Sars-cov-2 O-glycosylation Hcd-ethcd Lc-ms/ms 
ProteomicsMULTI-TARGETED FLAVONOID INHIBITION OF THE PATHOGENIC BACTERIUM STAPHYLOCOCCUS AUREUS: A Proteomic Characterization
Growth inhibition of the pathogen Staphylococcus aureus with currently available antibiotics is problematic in part due to bacterial biofilm protection. While Although the recently characterized natural products, including 3´,4´,5-trihydroxy-6,7-dimethoxy-flavone [1], 3´,4´,5,6,7-pentahydroxy-flavon...
ORGANISM(S): Staphylococcus aureus 
2017-05-30 | PXD006030 | Pride
Antibacterial flavonoids  lc-ms/ms proteomics  multi-targeted bacterial inhibition Staphylococcus aureus 
ProteomicsIntegrated Transcriptomics, Proteomics and Glycomics for a Deeper Insight of the Mechanism of Breast Cancer Brain Metastasis: Emphasizing on Glycosylation
Breast cancer brain metastasis has been recognized as one of the central issues in breast cancer research. Elucidation of the process and pathway that mediate this step is expected to provide important clues for a better understanding of breast cancer metastasis. Increasing evidence suggests that th...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD010506 | Pride
Integrative omics analysis Glycomics Transcriptomics Proteomics Breast cancer brain metastasis 
ProteomicsProteomic Analysis of Bradykinin Signaling in Podocytes
Diabetic kidney disease is the major cause of end-stage kidney failure worldwide. Podocyte damage is one of the hallmarks of diabetic nephropathy, where the loss of the podocyte filtration barrier leads to proteinuria and progressive renal damage. Bradykinin (BK) is a vasoactive peptide that was sho...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-08 | PXD010015 | Pride
Podocyte Bradykinin signaling Lc-ms/ms 
ProteomicsEffect of Chronic Methamphetamine Exposure on the Neuroproteomics of Rat Brain Tissues
Nowadays, drug abuse and addiction are serious public health problems in the USA. Methamphetamine (METH) is one of the most abused drugs, which is known to cause brain damage from repeated exposure on human. Herein, a proteomic study was applied to evaluate METH-induced brain protein dynamics follow...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-04-21 | PXD000915 | Pride
Chronic administration Proteomics Escalating dose Neuroproteomics Systems biology Drug abuse Methamphetamine 
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