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ProteomicsThe dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant
A century ago, influenza A virus (IAV) infection caused the 1918 flu pandemic and killed an estimated 20-40 million people. Pandemic IAV outbreaks occur when strains from animal reservoirs acquire the ability to infect and spread among humans. The molecular details of this species barrier are incomp...
ORGANISM(S): Homo sapiens (Human) Gallus gallus (Chicken) 
2019-11-11 | PXD015475 | Pride
Influenza a virus infection 
ProteomicsThe dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant
A century ago, influenza A virus (IAV) infection caused the 1918 flu pandemic and killed an estimated 20-40 million people. Pandemic IAV outbreaks occur when strains from animal reservoirs acquire the ability to infect and spread among humans. The molecular details of this species barrier are incomp...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD015474 | Pride
Influenza a virus Human Avian Newly synthesized proteins 
ProteomicsMutations in disordered regions cause disease by creating dileucine motifs - peptide-protein interaction screen
Many disease-causing missense mutations affect intrinsically disordered regions (IDRs) of proteins. Since these mutations do not affect protein structure, the molecular mechanism of their pathogenicity is enigmatic. Here, we employ a peptide-based proteomic screen to investigate the impact of mutati...
ORGANISM(S): Homo sapiens (Human) 
2018-09-13 | PXD010027 | Pride
Peptide array Ppi Protein-protein interaction Disordered regions 
ProteomicsMutations in disordered regions cause disease by creating dileucine motifs - BioID
Many disease-causing missense mutations affect intrinsically disordered regions (IDRs) of proteins. Since these mutations do not affect protein structure, the molecular mechanism of their pathogenicity is enigmatic. Here, we employ a peptide-based proteomic screen to investigate the impact of mutati...
ORGANISM(S): Homo sapiens (Human) 
2018-09-13 | PXD010061 | Pride
Bioid Proximity labeling 
UnknownDiagnostic accuracy and clinical implications of robotic assisted MRI-US fusion guided target saturation biopsy of the prostate.
Not available
S-EPMC8511036 | biostudies-literature
ProteomicsMutations in disordered regions cause disease by creating dileucine motifs - PRM dataset-
Mutations in intrinsically disordered regions (IDRs) of proteins are associated with a wide spectrum of diseases. Since IDRs lack a fixed three-dimensional structure, the molecular mechanism by which such mutations cause disease is often unknown. Here, we employ a peptide-based proteomic screen to i...
ORGANISM(S): Homo sapiens (Human) 
2018-09-13 | PXD010005 | Pride
Glut1 Disordered regions Prm Dileucin 
TranscriptomicsExpression data of IL-18 generated murine NK cells
We analyzed gene expression profiles of IL-18 generated murine NK cells in comparison to unstimulated, freshly isolated splenic NK cells. We identified a set of 1414 Affymetrix probe sets showing significant misregulation (Welch's T-test, p<0.05; Benjamini-Hochberg FDR corrected). IL-18 generated as...
ORGANISM(S): Mus musculus 
2012-07-10 | E-GEOD-33627 | biostudies-arrayexpress
ProteomicsThe dynamic proteome of Influenza A virus infection
We combined metabolic pulse labeling and quantitative shotgun proteomics to globally monitor protein synthesis upon infection of human cells with a human- and a bird-adapted IAV strain. While production of host proteins was remarkably similar, we observed striking differences in the kinetics of vira...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD011321 | Pride
Influenza Protein de novo synthesis Aha A549 Silac Avian flu Human flu 
ProteomicsIntegrated phosphoproteome and transcriptome analysis reveals Chlamydia-induced epithelial-to-mesenchymal transition in host cells
Chlamydia trachomatis are the etiological agents of a range of diseases and are epidemiologically associated with cervical and ovarian cancers. The interplay between host and chlamydia is highly complex, and to obtain panoramic view of the functional interplay, we performed combinatorial global phos...
ORGANISM(S): Homo sapiens (Human) 
2018-12-07 | PXD011960 | Pride
Chlamydia Phosphoproteomics 
ProteomicsFamilial Alzheimer disease mutation in SORL1 impairs release of neurotrophic extracellular vesicles by microglia
Coding mutations in SORL1, the gene encoding sortilin-related receptor with A-type repeats (SORLA) are common in individuals suffering from Alzheimer’s disease (AD) of unknown etiology. These findings suggest SORL1 as a novel familial disease gene causative of AD. SORL1 mutations characterized so fa...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD061828 | Pride
Alzheimer’s disease Extracellular vesicles Sorl1 
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