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TranscriptomicsExpression data from Burkitt's Lymphoma cell line BL2 transiently transfected with Epstein-Barr Virus miRNA mimics BART 18-5p, 10, 14*
Cellular targets for most of EBV miRNAs are not known. In our study, we aimed at identifying genes that are regulated by individual EBV mature miRNA, particularly BART 18-5p We used microarrays to explore the global gene expression (particularly the downregulated genes) targeted by EBV miRNA mimics....
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-58224 | biostudies-arrayexpress
GenomicsmiRNA expression in CTRL1790 cells transfected with miR mimics
miRNA expression in CTRL1790 cells transfected with miR mimics
PRJNA551972 | ENA
TranscriptomicsTransfection of primary neuronal cultures with miRNA mimics and inhibitors
We investigated functions of miRNAs at the level of the whole transcriptome of primary neurons. We transfected mouse E17.5 forebrain primary neuronal cultures (at four to six days of in vitro development) with miRNA mimics and inhibitors. After approximately 48 h post transfection we profiled the ef...
ORGANISM(S): Mus musculus 
2011-12-31 | E-MTAB-686 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse embryonic stem cell lines with Dgcr8 mutations to investigate the broad role of miRNAs and individual miRNAs through the reintroduction of miRNA mimics
These experiments were conducted as part of a study to derive the targets of miRNAs. Two independent BayGenomics mouse embryonic stem cell lines (XH157 and XG058), each bearing a gene trap between exons 9 and 10 of the Dgcr8 locus (ENSMUST00000115633, Ensembl v53) were further mutagenised by the tar...
ORGANISM(S): Mus musculus 
2012-08-20 | E-MTAB-418 | biostudies-arrayexpress
UnknownQuantification of therapeutic miRNA mimics in whole blood from nonhuman primates.
Not available
S-EPMC3982984 | biostudies-literature
TranscriptomicsEvolution of human-specific microRNA miR-941 [miRNA transfection]
miRNA-mediated gene expression silencing has previously been shown to be important for a variety of physiological and pathological processes. Here, we have explored the role of one bona fide human-specific miRNA (miR-941) in evolution of the human-specific expression and function. Using combination ...
ORGANISM(S): Macaca mulatta 
2012-12-20 | E-GEOD-35620 | biostudies-arrayexpress
TranscriptomicsA systematic evaluation of miRNA: mRNA interactions involved in the migration and invasion of breast cancer cells [miRNA Array]
In this study we performed a systematic evaluation of functional miRNA-mRNA interactions associated with the aggressiveness of breast cancer cells using a combination of integrated miRNA and mRNA expression profiling, bioinformatics prediction, and functional assays. Analysis of the miRNA expression...
ORGANISM(S): Homo sapiens 
2013-06-03 | E-GEOD-40056 | biostudies-arrayexpress
ProteomicsDeregulated Expression of the 14q32 miRNA Cluster in Clear Cell Renal Cell Carcinomas
Clear cell renal cell carcinomas (ccRCC) are characterized by arm-wide chromosomal alterations. Loss at 14q is associated with disease aggressiveness in ccRCC, which responds poorly to chemotherapeutics. The 14q locus contains one of the largest miRNA clusters in the human genome; however, little is...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD036428 | Pride
Lpa Dia Q-tof Claudin-1 14q32 Iron Dnmt1 Timstof pro Ccrcc Atxn2 
TranscriptomicsMicroRNA expression and regulation in human, chimpanzee, and macaque brain
Among other factors, changes in gene expression on the human evolutionary lineage have been suggested to play an important role in the establishment of human-specific phenotypes. However, the molecular mechanisms underlying these expression changes are largely unknown. Here, we have explored the rol...
ORGANISM(S): Homo sapiens 
2011-10-17 | E-GEOD-26545 | biostudies-arrayexpress
TranscriptomicsIntrahepatic miRNA/mRNA expression in non-responders to pegylated interferon plus ribavirin combination therapy for chronic hepatitis C (miRNA microarray data)
Despite advance in interferon-based treatment for chronic hepatitis C, difficult-to-treat patients remain in existence yet. To identify key genes involved in difficult-to-treat characteristics, gene expression patterns of miRNA and RNA were analyzed by profiling pretreatment liver tissues from five ...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-45179 | biostudies-arrayexpress
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