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GenomicsEic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly
CENP-A chromatin the foundation for kinetochore assembly in all eukaryotes. CENP-A is incorporated outside of S phase and depends on its chaperone HJURPScm3, and Mis18 in vertebrates and fission yeast. The recruitment of Mis18 and HJURPScm3 to centromeres is cell cycle regulated. Vertebrate Mis18 a...
ORGANISM(S): Schizosaccharomyces pombe 
2014-05-19 | E-GEOD-54685 | biostudies-arrayexpress
GenomicsEic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly
CENP-A chromatin the foundation for kinetochore assembly in all eukaryotes. CENP-A is incorporated outside of S phase and depends on its chaperone HJURPScm3, and Mis18 in vertebrates and fission yeast. The recruitment of Mis18 and HJURPScm3 to centromeres is cell cycle regulated. Vertebrate Mis18 as...
ORGANISM(S): Schizosaccharomyces pombe 
2014-05-19 | GSE54685 | GEO
UnknownMolecular basis for Cdk1-regulated timing of Mis18 complex assembly and CENP-A deposition.
Not available
S-EPMC5452045 | biostudies-literature
ProteomicsIdentification of HJURP binding determinants on the Mis18 complex using photo-cross-linking and mass spectrometry
In the early G1 phase of the cell cycle, human HJURP is recruited to centromeres by the Mis18 complex, which consists of Mis18α, Mis18β and M18BP1. This interaction of HJURP with the Mis18 complex is essential for CENP-A deposition and the preservation of centromere identity. To identify the binding...
ORGANISM(S): Homo sapiens (Human) 
2019-08-01 | PXD013339 | Pride
Photo-cross-linking Q-exactive Abk Human Kinetochore Centromere Protein complex Bpa Stavrox 
UnknownSubunit interactions and arrangements in the fission yeast Mis16-Mis18-Mis19 complex.
Not available
S-EPMC6677171 | biostudies-literature
UnknownStructural basis for Mis18 complex assembly and its implications for centromere maintenance.
Not available
S-EPMC11315898 | biostudies-literature
ProteomicsDirect recruitment of Mis18 to interphase spindle poles promotes CENP-A chromatin assembly.
CENP-A chromatin specifies mammalian centromere identity, and its chaperone HJURP replenishes CENP-A when recruited by the Mis18 complex (Mis18C) via M18BP/KNL2 to CENP-C at kinetochores during interphase. However, the Mis18C recruitment mechanism remains unresolved in species lacking M18BP1, such a...
ORGANISM(S): Schizosaccharomyces pombe 927 
2023-09-18 | PXD045191 | Pride
Mis18 complex Fission yeast Cenp-a chromatin Centromere 
UnknownDifferential Binding Partners of the Mis18α/β YIPPEE Domains Regulate Mis18 Complex Recruitment to Centromeres.
Not available
S-EPMC4899240 | biostudies-literature
ProteomicsPLK1-Mediated Phosphorylation Cascade Activates Mis18 Complex to Ensure Centromere Inheritance
Accurate chromosome segregation requires the attachment of spindle microtubules to centromeres, which are epigenetically defined by the enrichment of CENP-A nucleosomes. During DNA replication, existing CENP-A nucleosomes undergo dilution as they get redistributed among the two DNA strands. To prese...
ORGANISM(S): Homo sapiens (Human) 
2025-02-15 | PXD053197 | Pride
Hjurp Plk1 Mis18 Phosphorylation Cross-linking mass spectrometer 
ProteomicsStructural basis for the assembly of Mis18a/b core modules
The centromere, defined by the enrichment of CENP-A (a Histone H3 variant) containing nucleosomes, is a specialised chromosomal locus that acts as a microtubule attachment site. To preserve centromere identity, CENP-A levels must be maintained through active CENP-A loading during the cell cycle. A c...
ORGANISM(S): Homo sapiens (Human) 
2024-09-25 | PXD052964 | Pride
Centromere Mass spectrometry 
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