Sort   by:  
 Page size 
ProteomicsEfficient checkpoint signaling depends on the integrated activities of Bub1 and the RZZ complex
Kinetochore localized Mad1 is essential for generating a “wait anaphase” signal during mitosis hereby ensuring accurate chromosome segregation. Inconsistent models for the function and quantitative contribution of the two mammalian Mad1 kinetochore receptors: Bub1 and the Rod-Zwilch-ZW10 (RZZ) compl...
ORGANISM(S): Homo sapiens (Human) 
2019-02-19 | PXD012235 | Pride
Mitosis proteomics bub1 
ProteomicsSelf-priming of Plk1 binding to BubR1 ensures accurate mitotic progression
Plk1 is a key mitotic kinase that localizes to distinct subcellular structures to promote accurate mitotic progression. Plk1 recruitment depends on direct interaction between polo-box domain (PBD) on Plk1 and PBD binding motif (PBD BM) on the interactors. However, recent study showed that PBD BM alo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-31 | MSV000096264 | MassIVE
UnknownJuxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly.
Not available
S-EPMC9605988 | biostudies-literature
UnknownPICH impacts the spindle assembly checkpoint via its DNA translocase and SUMO-interaction activities.
Not available
S-EPMC11806350 | biostudies-literature
ProteomicsPlasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex
Mitosis in Plasmodium spp., the causative agent of malaria, is fundamentally different from model eukaryotes, proceeding via a bipartite microtubule organising centre (MTOC) and lacking canonical regulators such as Polo and Bub1 kinases. During schizogony, asynchronous nuclear replication produces a...
ORGANISM(S): Plasmodium berghei ANKA 
2026-01-13 | PXD068821 | Pride
Male gametogony Plasmodium Aurora kinase Cytokinesis Warwick_rtp Spindle Chromosomal passenger complex (cpc) Incenp Karyokinesis Mtoc Transmission 
ProteomicsLC-MS/MS identification of differentially expressed proteins in carboplatin resistant Triple Negative Breast Cancer
Triple negative breast cancer (TNBC) is the subtype of breast cancer most lacking in efficient treatment options. Although many TNBCs show remarkable responses to carboplatin-based chemotherapy, they often develop resistance over time. With increasing use of carboplatin in clinics, there is a pressi...
ORGANISM(S): Homo sapiens (Human) 
2021-07-07 | PXD021726 | Pride
Lc-ms/ms identification of differentially expressed proteins in carboplatin resistant triple negative breast cancer 
ProteomicsConserved signalling functions for Mps1, Mad1 and Mad2 in the Cryptococcus neoformans spindle checkpoint
Cryptococcus neoformans is an opportunistic, human fungal pathogen which undergoes fascinating switches in cell cycle control and ploidy when it encounters stressful environments such as the human lung. Here we carry out a mechanistic analysis of the spindle checkpoint which regulates the metaphase ...
ORGANISM(S): Cryptococcus neoformans 
2024-05-27 | PXD052327 | Pride
Cryptococcus neoformans Mad2 Mad1 Spindle checkpoint Mps 
Sort   by:  
 Page size