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ProteomicsPhosphosites of the yeast centrosome component Spc110 contribute to mitotic exit
Spc110 is an essential component of the spindle pole body (SPB), the yeast equivalent of the centrosome, that recruits the gamma-tubulin complex to the nuclear side of SPB to form the mitotic spindle. Here we identify two phosphosites (S11 and S36) in old (from maternal origin) Spc110. Yeast expres...
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) 
2023-04-03 | PXD033085 | JPOST Repository
TranscriptomicsGene Expression Profiling for Plk2 -/- mammary gland
Identify gene expression changes in the absence of Plk2 Disruptions in polarity and mitotic spindle orientation contribute to the progression and evolution of tumorigenesis. However, little is known about the molecular mechanisms regulating these processes in vivo. Here we demonstrate that Polo-like...
ORGANISM(S): Mus musculus 
2014-05-20 | E-GEOD-50003 | biostudies-arrayexpress
ProteomicsCAMK2D recruits RNF8-MAD2 complex to RNA splicing proteins for mitotic checkpoint activation in GBM
Glioblastoma (GBM) is a lethal brain tumor with remarkable intra-tumoral heterogeneity and therapeutic resistance which is linked to glioma stem cell (GSC). GSC contains unstable genome and elevated genomic instability could impair GSC self-renewal and tumorigenicity. In addition, GSC displays great...
ORGANISM(S): Homo Sapiens (human) 
2023-07-21 | PXD038123 | JPOST Repository
ProteomicsSignaling pathways altered at the mitotic spindle in clathrin depleted cells
We present a snapshot of the regulation of mitotic-spindle proteins and their phosphorylation status in the absence of clathrin during metaphase. A reference list of proteins and phosphosites identified from a mitotic spindle preparation was generated using a label-free and a parallel chemical dimet...
ORGANISM(S): Homo sapiens (Human) 
2016-05-17 | PXD001603 | Pride
Hela Chc knock-down Tio2 Dimethylation Scx High ph reverse phase Lc-ms/ms 
ProteomicsFAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning
The concerted action of many protein kinases helps orchestrate the error-free progression through mitosis of mammalian cells. The roles and regulation of some prominent mitotic kinases, such as cyclin-dependent kinases, are well-established. However, these and other known mitotic kinases alone canno...
ORGANISM(S): Homo sapiens (Human) 
2019-07-15 | PXD013808 | Pride
Protein kinase ck1α Mitotic spindle Fam83d 
ModelsIbrahim2008 - Mitotic Spindle Assembly Checkpoint - Convey variant
Ibrahim2008 - Mitotic Spindle Assembly Checkpoint - Convey variant The Mitotic Spindle Assembly Checkpoint ((M)SAC) is an evolutionary conserved mechanism. This model incorporates the perspectives of three central control pathways, namely Mad1/Mad2 induced Cdc20 sequestering based ...
2024-09-02 | BIOMD0000000187 | BioModels
ModelsIbrahim2008 - Mitotic Spindle Assembly Checkpoint - Dissociation variant
Ibrahim2008 - Mitotic Spindle Assembly Checkpoint - Dissociation variant The Mitotic Spindle Assembly Checkpoint ((M)SAC) is an evolutionary conserved mechanism. This model incorporates the perspectives of three central control pathways, namely Mad1/Mad2 induced Cdc20 sequestering ...
2024-09-02 | BIOMD0000000186 | BioModels
Proteomics19S proteasome loss regulates mitotic spindle assembly through a ubiquitin-independent degradation mechanism
During regulated protein degradation, the 26S proteasome recognizes ubiquitinated substrates through its 19S particle and then degrades them in its 20S enzymatic core. Despite this close interdependency between proteasome subunits, we demonstrate that knockouts from different proteasome subcomplexes...
ORGANISM(S): Homo sapiens (Human) 
2025-06-24 | PXD065357 | Pride
Proteasome Mitosis Spindle Degradation Kinesin Ubiquitin 
ProteomicsCentrosomal ALIX regulates mitotic spindle orientation by modulating astral microtubule dynamics
The orientation of the mitotic spindle (MS) is tightly regulated, but the molecular mechanisms are incompletely understood. Here we report a novel role for the multifunctional adaptor protein ALG-2-interacting protein X (ALIX) in regulating MS orientation in addition to its well-established role in ...
ORGANISM(S): Homo sapiens (Human) 
2018-06-04 | PXD009747 | Pride
Mitotic spindle orientation Alix Microtubule G-tubulin Map1s 
ModelsCaydasi2012 - Inhibition of Tem1 by the GAP complex in Spindle Position Checkpoint
This model is from the article: A dynamical model of the spindle position checkpoint Ayse Koca Caydasi, Maiko Lohel, Gerd Grünert, Peter Dittrich, Gislene Pereira, Bashar Ibrahim Molecular Systems Biology 2012; 582 doi: 10.1038/msb.2012.15 ...
2024-09-02 | BIOMD0000000701 | BioModels
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