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TranscriptomicsThe Anti-Aging and Tumor Suppressor Protein Klotho Affects Signaling Pathwaysin a Human Oligodendroglioma Cell Line
Klotho functions as an aging suppressor, which, in mice, extends lifespan when overexpressed and accelerates development of aging-like phenotypes when disrupted. Klotho is mainly expressed in brain and kidney and is secreted into the serum and CSF. We have previously shown that Klotho is reduced in ...
ORGANISM(S): Homo sapiens 
2014-06-09 | E-GEOD-51536 | biostudies-arrayexpress
ProteomicsCannabidiol displays proteomic similarities to antipsychotics in cuprizone-exposed human oligodendrocytic cell line MO3.13
We employed nano-chromatography coupled with mass spectrometry to investigate the proteomic response to benztropine,cannabidiol, clozapine, and haloperidol, both in healthy oligodendrocytic cells and in a cuprizone-based toxicity model, using the human oligodendrocyte precursor cell line MO3.13.
ORGANISM(S): Homo sapiens (Human) 
2021-11-11 | PXD028419 | Pride
Phytocannabinoid Schizophrenia Haloperidol Mo3.13 cell line Benztropine Proteome Clozapine 
ProteomicsProteome analysis of the MO3.13 cell line from human oligodendrocytes
MO3.13 is an immortal human-human hybrid cell line that express phenotypic characteristics of primary oligodendrocytes. It was created by fusing a 6-thioguanine-resistant mutant of the human rhabdomyosarcoma RD (cancer of skeletal muscle) with adult human oligodendrocytes by a lectin-enhanced polyet...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-12 | MSV000083971 | MassIVE
UnknownCannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13.
Not available
S-EPMC8193732 | biostudies-literature
ProteomicsProteome analysis of the MO3.13 cell line from human oligodendrocytes
MO3.13 is an immortal human-human hybrid cell line that express phenotypic characteristics of primary oligodendrocytes. It was created by fusing a 6-thioguanine-resistant mutant of the human rhabdomyosarcoma RD (cancer of skeletal muscle) with adult human oligodendrocytes by a lectin-enhanced polyet...
ORGANISM(S): Homo sapiens (Human) 
2013-10-09 | PXD000263 | Pride
Human  oligodendrocytes  proteome  c-hpp 
UnknownEBI2 Is Temporarily Upregulated in MO3.13 Oligodendrocytes during Maturation and Regulates Remyelination in the Organotypic Cerebellar Slice Model.
Not available
S-EPMC8122433 | biostudies-literature
ProteomicsComprehensive identification of proteins expressed by human oligodendroglia cell line
Oligodendrocytes are a type of neuroglia that have provide trophic support and insulation to axons in central nervous system. A proper differentiation of oligodendrocyte precursor cells is crucial for central nervous system myelination and development. Such maturation proccess can be induced in vitr...
ORGANISM(S): Homo sapiens (Human) 
2017-09-27 | PXD004696 | Pride
Udmse Proteome Oligodendrocytes 
TranscriptomicsThe Anti-Aging and Tumor Suppressor Protein Klotho Affects Signaling Pathwaysin a Human Oligodendroglioma Cell Line
Klotho functions as an aging suppressor, which, in mice, extends lifespan when overexpressed and accelerates development of aging-like phenotypes when disrupted. Klotho is mainly expressed in brain and kidney and is secreted into the serum and CSF. We have previously shown that Klotho is reduced in ...
ORGANISM(S): Homo sapiens 
2014-06-09 | GSE51536 | GEO
UnknownThe anti-aging and tumor suppressor protein Klotho enhances differentiation of a human oligodendrocytic hybrid cell line.
Not available
S-EPMC5154549 | biostudies-literature
ProteomicsCannabinoids modulate proliferation, differentiation, and migration signaling pathways in oligodendrocytes
To elucidate the specific molecular signals associated with the activation or blockade of CB1 and CB2 receptors in this glial cell, mass spectrometry-based proteomics and in silico biology tools were used to determine which signaling pathways and molecular mechanisms are triggered in a human oligode...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD031923 | Pride
Proteomics Cb1 Endocannabinoids Cb2 Cannabidiol 
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