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ProteomicsProteomic Analysis of Diabetic Retinas
As a metabolic disease, diabetes often leads to health complications such as heart failure, nephropathy, neurological disorders, and vision loss. Diabetic retinopathy (DR) affects as many as 100 million people worldwide. The mechanism of DR is complex and known to impact both neural and vascular com...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-16 | PXD044269 | Pride
Retina Proteomics diabetes mellitus Mouse 
ProteomicsProteomic analysis of urinary microvesicles reveal biomarkers for neurologic disease
Background- Extracellular vesicles (EVs) harbor thousands of proteins that hold promise for biomarker development. Usually difficult to purify, EVs in urine are relatively easily obtained and have demonstrated efficacy for kidney disease prediction. Herein, we further characterize the proteome of ur...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD013710 | Pride
Biomarkers  neurodegeneration  exosomes  parkinson's disease  alzheimer's disease 
ProteomicsProteomic analysis of urinary microvesicles - logitudinal Study
This is a small pilot study for two voluteers with average diets that gave morning urine specimens across six samplings over 10-11 days to determine the day to day stability of extracellular vesical proteomes.
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD013700 | Pride
Proteomics Extracellular vesicals Urine Logitudinal 
ProteomicsProteomic Analysis of Diabetic Retinas (proteoglycomics data only)
As a metabolic disease, diabetes often leads to health complications such as heart failure, nephropathy, neurological disorders, and vision loss. Diabetic retinopathy (DR) affects as many as 100 million people worldwide. The mechanism of DR is complex and known to impact both neural and vascular com...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-16 | PXD044270 | Pride
Mouse Proteomics Retina Diabetes mellitus 
Proteomics14-3-3 protects AMPK phosphorylated TET2 from dephosphorylation by PP2A
Ten-eleven translocation-2 (TET2) is a member of the methylcytosine dioxygenase family of enzymes implicated in cancer and in aging due to its role as a global epigenetic modifier. TET2 has a large N-terminal domain followed by a catalytic C-terminal. Previous reports have demonstrated that the cata...
ORGANISM(S): Homo sapiens (Human) 
2020-01-13 | PXD016160 | Pride
5hmc Ampk Pp2a Tet2 Post-translational modification 14-3-3 
ProteomicsEarly-adulthood spike in protein translation drives aging via juvenile hormone/germline signaling
Protein translation (PT) declines with age in invertebrates, rodents, and humans. It has been assumed that elevated PT at young ages is beneficial to health and PT ends up dropping as a passive byproduct of aging. In Drosophila, we show that a transient elevation in PT during early-adulthood exerts ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-10-24 | PXD044118 | Pride
Proteostasis Aging Proteomics Lcms2 Drosophila 
ProteomicsProteomic signatures of retinal pigment epithelium-derived exosomes in myopic and non-myopic tree shrew eyes
Purpose: The retinal pigment epithelium (RPE) transmits growth signals from the neural retina to the choroid in the emmetropization pathway, but the underlying molecular mechanisms remain poorly understood. Here, we compared the proteomic profiles of RPE-derived exosomes between myopic and non-myopi...
ORGANISM(S): Tupaia 
2026-08-31 | PXD062092 | Pride
Exosomes Tree shrews Proteomics Myopia Retinal pigment epithelium Emmetropization 
ProteomicsSTRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells
STRAP protein was IP'd and corresponding binding proteins were identified by high resolution nanoLCMS2 vs a control experiment.
ORGANISM(S): Mus musculus (Mouse) 
2020-09-10 | PXD015371 | Pride
Proteomics Strap Stem cells 
ProteomicsIncreased levels of extracellular matrix proteins in extracellular vesicles from brains of aged mice.
Extracellular vesicles (EVs) have several functions in the brain, serving as a mode of intercellular communication and as a pathway for disposal of cellular debris. While these functions serve to maintain healthy brain function, they may also contribute to diseases affecting the brain. EVs also chan...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD052797 | Pride
Aging Extracellular vesicles Extracellular matrix Lcms Mouse model Proteomics 
ProteomicsGlobal proteomics and affinity mass spectrometry analysis of human Schwann cells indicates that loss of NF1 alters cellular and mitochondrial metabolism - PPI SC study
Detailed global proteomics analysis for NF1 deficient cells and tissues is lacking. We investigated proteomes from immortalized human Schwann cells with (+/+) and without (-/-) NF1 to evaluate potential biomarkers and targets in NF1 deficient cells. We identified over 1900 proteins in both cell li...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052442 | Pride
Nf1 Ppi Lcms Schwann cells 
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