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ProteomicsHuman whole blood processed with VAMS device
This project tested the use of a volumemetric absorptive microsampling device as a substrate to prepare whole blood for proteomic analysis by LC-MS. We demonstrated that VAMS are a useful substrate to trap proteins from blood, wash them to reduce highly abundant protein species which enabled single ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-21 | PXD028605 | Pride
Lc-ms Plasma Blood Microsampling Vams Human 
ProteomicsPseudomonas aeruginosa proteome under hypoxic stress conditions mimicking the cystic fibrosis lung
Pseudomonas aeruginosa is a Gram-negative, opportunistic bacterium and a major etiological agent in monogenic disease cystic fibrosis (CF). High density colonies of P. aeruginosa are often isolated from hypoxic mucus plugs in respiratory tract of CF patients, indicating high adaptive capacities of t...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2017-08-29 | PXD007233 | Pride
Cystic fibrosis Hypoxia Pseudomonas aeruginosa Tmt-ms Swath-ms 
ProteomicsMultiphasic chip performance characterization using human thyroid cancer cell line SW1736 and human plasma
Development of an online peptide fractionation system comprising a multiphasic LC chip that integrates reversed phase and strong cation exchange chromatography upstream of the MS based on the multi-dimensional protein identification technology (mudPIT). Chips were assessed in terms of chromatographi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000081545 | MassIVE
ProteomicsMass spectrometric detection of proteins associated with lymph node metastasis in T1/2 colorectal cancer from FFPE archival specimens
Surgical resection of colorectal cancers (CRC) that have not invaded beyond the bowel wall (i.e. Stage I) can achieve 5-year patient survival rates exceeding 90%. In the majority of Stage I cases with T1 (submucosal) or T2 (not beyond the muscularis propria) depth of tumour invasion, surgery alone i...
ORGANISM(S): Homo sapiens (Human) 
2021-01-14 | PXD020808 | Pride
Prm Ffpe Dia Colorectal cancer 
ProteomicsProteomics of thyroid tumours - Proteomics of thyroid tumours provides new insights into their molecular composition and changes associated with malignancy
Although most thyroid tumours are benign, thyroid cancer represents the most common malignancy of the endocrine system, comprising mainly follicular and papillary thyroid carcinomas (FTC and PTC, respectively). Previous studies have shed some light on the molecular pathogenesis of thyroid cancer but...
ORGANISM(S): Homo sapiens (Human) 
2017-05-03 | PXD002732 | Pride
Swath Thyroid cancer proteomics 
ProteomicsData Independent Acquisition of plasma biomarkers of response to Neoadjuvant Chemotherapy in Pancreatic Ductal Adenocarcinoma
The detection of disease-related plasma biomarkers has challenged the proteomic community for years. On the one hand there are many attractive features including the ease of collection and small volume needed for analysis, but on the other hand, the presence of high abundance proteins complicates te...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD020437 | Pride
Complement Plasma Neoadjuvant chemotherapy Pancreatic cancer Biomarker Data-independent acquisition 
ProteomicsPhosphoproteomic analysis of cell-based resistance to BRAF inhibitor therapy in melanoma
The treatment of melanoma by targeted inhibition of the mutated kinase BRAF with small molecules only temporarily suppresses metastatic disease. In the face of chemical inhibition tumor plasticity, both innate and adaptive, promotes survival through the biochemical and genetic reconfiguration of cel...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD002079 | Pride
Kinases Phosphoproteomics Braf Drug resistance Mass spectrometry Label free quantitation 
ProteomicsData independent MS phenotyping of patient derived melanoma cell lines
Phenotyping of patient derived Stage III and IV melanoma cell lines to predict drug response
ORGANISM(S): Homo sapiens (Human) 
2018-10-11 | PXD002725 | Pride
Human Melanoma Swath Drug resistance 
ProteomicsData independent MS phenotyping of melanoma tissue specimens
Phenotyping of Stage III BRAF or NRAS mutant melanoma tissue specimens to predict drug response and patient survival
ORGANISM(S): Homo sapiens (Human) 
2018-10-11 | PXD007083 | Pride
Human Melanoma Swath Drug resistance 
ProteomicsRespiratory complex II - Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints
Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints
ORGANISM(S): Homo sapiens (Human) 
2018-10-18 | PXD009656 | Pride
Mitochondria  sdha  energy utilization 
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