Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of mouse intestine in ENU mutagenesis mouse strains with missense mutations in Muc2 mucin and ER stress
Background; MUC2 mucin produced by intestinal goblet cells is the major component of the intestinal mucus barrier. MUC2 homo-oligomerizes intracellularly into large secreted polymers which give mucus its viscous properties. The inflammatory bowel disease (IBD) ulcerative colitis is characterized by...
ORGANISM(S): Mus musculus 
2008-04-06 | E-GEOD-9913 | biostudies-arrayexpress
TranscriptomicsA GNAS mutation found in pancreatic intraductal papillary mucinous neoplasms induces drastic alterations of gene expression profiles with upregulation of mucin genes.
GNAS, a gene encoding G-protein stimulating alpha subunit, is frequently mutated in intraductal papillary mucinous neoplasms (IPMNs), which is an indolent and slow-growing pancreatic neoplasm that secretes abundant mucin. GNAS mutation is not observed in conventional ductal adenocarcinomas of the pa...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-53350 | biostudies-arrayexpress
TranscriptomicsRole of the polypeptide N-acetylgalactosaminyltransferase 3 in ovarian cancer progression: possible implications in abnormal mucin O-glycosylation
Previously, we have identified the polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3) gene as notably hypomethylated in low-malignant potential (LMP) and high-grade (HG) serous epithelial ovarian tumors, compared to normal ovarian tissues. Here we show that GALNT3 is strongly overexpressed in ...
ORGANISM(S): Homo sapiens 
2014-05-22 | E-GEOD-52602 | biostudies-arrayexpress
GenomicsHUVEC cell transcriptome response to Zaire Ebola virus (EBOV) and mutant lacking the mucin domain (deltamucin-EBOV)
HUVEC cell transcriptome response to Zaire Ebola virus (EBOV) and mutant lacking the mucin domain (deltamucin-EBOV)
PRJNA864745 | ENA
ProteomicsAn unusual dual sugar-binding lectin domain controls the substrate specificity of a mucin-type O-glycosyltransferase
N-acetylgalactosaminyl transferases (GalNAc-Ts) initiate mucin-type O-glycosylation, an abundant and complex post-translational modification that regulates host-microbe interactions, tissue development, and metabolism. GalNAc-Ts contain a C-terminal lectin domain consisting of three homologous repea...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD047845 | Pride
Muc1 O-glycosylation Structure Lectin domain Substrate specificity 
UnknownSialidase Unmasks Mucin Domain Epitopes of Lubricin.
Not available
S-EPMC5084523 | biostudies-literature
ProteomicsCerebrovascular proteome changes with mucin-domain glycoprotein degradation and core 1 mucin-type O-glycan downregulation
Mucin-domain glycoproteins are overlooked yet crucial components of the brain endothelial glycocalyx, playing essential roles in maintaining cerebrovascular integrity and function. Dysregulation of these glycoproteins has been implicated in aging and neurodegenerative disease, including Alzheimer’s ...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-17 | PXD058690 | Pride
Vasculature Timstof Mouse Brain Lc-ms/ms 
ModelsKees2018 - Genome-scale constraint-based model of the mucin-degrader Akkermansia muciniphila
Kees2018 - Genome-scale constraint-based model of the mucin-degrader Akkermansia muciniphila This model is described in the article: Model-driven design of a minimal medium for Akkermansia muciniphila confirms mucus adaptation. van der Ark KCH, Aalvink S, Suarez-D...
2021-02-15 | MODEL1710040000 | BioModels
TranscriptomicsHUVEC cell transcriptome response to Zaire Ebola virus (EBOV) and mutant lacking the mucin domain (deltamucin-EBOV)
The purpose is to obtain samples for mRNA analysis in HUV-EC-C cells, a human endothelial cell line isolated from the vein of the umbilical cord, using the following viruses obtained by reverse genetics: Zaire Ebola virus wild-type in the ΔVP30 background (deltaVP30-WT) and mutant lacking the mucin ...
ORGANISM(S): Homo sapiens 
2022-08-02 | GSE210189 | GEO
ProteomicsRevealing the human cancer-associated mucinome
Mucin domains are densely O-glycosylated modular protein domains found in a wide variety of cell surface and secreted proteins. Mucin-domain glycoproteins are key players in a host of human diseases, especially cancer, but the scope of the mucinome remains poorly defined. Recently, we characterized ...
ORGANISM(S): Homo sapiens (Human) 
2022-06-29 | PXD024995 | Pride
Mucin Cancer Mucinase Proteomics Mucinome Mass spectrometry Glycoproteomics O-glycosylation 
Sort   by:  
 Page size