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ProteomicsBiomechanical rigidity and quantitative proteomics analyses of segmental regions of the ocular trabecular meshwork at physiologic and elevated pressures
The extracellular matrix (ECM) of the ocular trabecular meshwork (TM) builds resistance to aqueous humor outflow, thereby regulating intraocular pressure (IOP). Glaucoma, a leading cause of blindness worldwide, is associated with changes in the ECM of the TM. The elastic modulus indicates glaucomato...
ORGANISM(S): Homo sapiens (Human) 
2018-01-22 | PXD006424 | Pride
Glaucoma Biomechanical rigidity High resolution mass spectrometry Multi-notch isolation Extended multiplexing Trabecular mesh Quantitative proteomics Human Tandem mass tags 
UnknownHow does the level of pulmonary venous isolation compare between pulsed field ablation and thermal energy ablation (radiofrequency, cryo, or laser)?
Not available
S-EPMC8576283 | biostudies-literature
ProteomicsUSP28 enables oncogenic transformation of respiratory cells and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K.
Oncogenic transformation of lung epithelial cells is a multi-step process, frequently starting with the inactivation of tumor suppressors and subsequent activating mutations in proto-oncogenes, such as members of the PI3K or MAPK family. Cells undergoing transformation have to adjust to changes, suc...
ORGANISM(S): Homo sapiens (Human) 
2022-04-08 | PXD032810 | Pride
Braf Buparlisib C-jun Vemurafenib Usp28 Lung cancer Egfr Pik3ca C-myc Hras gefitinib 
ProteomicsStatistical models for the analysis of isobaric Tags multiplexed quantitative proteomics
ABSTRACT: Mass spectrometry is being used to identify protein biomarkers that can facilitate development of drug treatment. Mass spectrometry based proteomics results in complex proteomic data that is hierarchical in nature often with small sample size studies. Generalized linear models (GLM) is th...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2017-07-28 | PXD005486 | Pride
Statistical models : proteomics Tmt Mixed models Biomarkers 
UnknownA tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb E3 ligases.
Not available
S-EPMC4355479 | biostudies-literature
ProteomicsHYpro16: A Two-Proteome Mixture to Assess Interference in Isobaric Tag-Based Sample Multiplexing Experiments
Isobaric tagging is a powerful strategy for global proteome profiling. A caveat of isobaric tag-based quantification is “interference” which may be caused by co-eluting peptides that are co-isolated, co-fragmented, and co-analyzed, thereby confounding quantitative accuracy. Here, we present a two-pr...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2021-08-16 | PXD020815 | Pride
Multiplex Tmt Sps-ms3 Standard Lumos Multi-notch 
ProteomicsGrowth media-based proteome remodeling of three microorganisms using sample multiplexing
The choice of growth media is a very important consideration of any cell-based proteomics experiment. Alterations thereof may result in differences in basal proteomes simply due to disparities in the metabolite composition of the media. We investigate the effect of growth media on the proteomes of t...
ORGANISM(S): Schizosaccharomyces pombe 927 Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2021-05-11 | PXD020816 | Pride
Microorganism Tmt Sps-ms3 Lumos Multi-notch 
UnknownA multi-omics longitudinal study of the murine retinal response to chronic low-dose irradiation and simulated microgravity.
Not available
S-EPMC9547011 | biostudies-literature
ProteomicsData Descriptor: Proteomic profiling across breast cancer cell lines and models
We performed quantitative proteomics of 60 human-derived breast cancer cell lines to a depth of ~13,000 proteins. The resulting high-throughput datasets were assessed for quality and reproducibility. We used the two omics datasets to identify and characterize the subtypes of breast cancer and showed...
ORGANISM(S): Homo sapiens (Human) 
2023-03-15 | PXD026581 | Pride
Protein expression Tmt Proteomic profiling Quantitative proteomics Breast cancer cell lines 
ProteomicsData Descriptor: Proteomic profiling across breast cancer cell lines and models
We performed quantitative proteomics and phosphoproteomics of 43 human-derived breast cancer cell lines to a depth of 11, 000 proteins and 45,000 phosphopeptides respectively. The resulting high-throughput datasets were assessed for quality and reproducibility. We used the two omics datasets to iden...
ORGANISM(S): Homo sapiens (Human) 
2023-07-03 | PXD017494 | Pride
Human Breast cancer Cancer cell lines Lincs 
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