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ProteomicsSlowing prion disease via M1 muscarinic receptors is associated with reduced neuroinflammation and down-regulation of neurodegenerative disease markers
Currently there are no treatments that can slow or halt the progression of dementia’s including Alzheimer’s disease. Here we investigate the possibility that activation of the M1-muscarinic receptor (M1-receptor), which is highly expressed in the brain and that shows pro-cognitive properties, might ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-14 | PXD025561 | Pride
G protein-coupled receptor Alzheimer’s disease Neuroinflammation Warwick_rtp Positive allosteric modulators Transcriptomic Prion disease Proteomic Neurodegeneration Neurodegenerative disease M1 muscarinic acetylcholine receptor 
ProteomicsTwo Types of Axonal Muscarinic Acetylcholine Receptors Mediate Formation of Saliva Cocktail in the Tick Ixodes ricinus
The long blood feeding duration of hard ticks relies on the continuous modulation of saliva composition to manipulate host haemostatic and immune systems. While the exogenous muscarinic acetylcholine receptor (mAChR) agonist, pilocarpine, is a potent inducer of tick salivation, the underlying contro...
ORGANISM(S): Ixodes ricinus 
2026-02-05 | PXD055362 | Pride
Synganglion Muscarinic receptors Neurosecretory cells Pharmacology Tick Axons Saliva Salivary gland acini 
TranscriptomicsIsolation of fetal human CD140a and O4-defined oligodendrocyte progenitor cells.
Human fetal tissue dissociates between 18-22wk gestational age were FACS sorted on the basis of CD140a (PDGFRA) and O4 antigens. Each population was profiled immediately following FACS. 20 samples, 4 groups (FACS-sorted cell populations), between 3 and 6 replicates in each group, each replicate is f...
ORGANISM(S): Homo sapiens 
2015-03-04 | E-GEOD-32589 | biostudies-arrayexpress
ProteomicsmPFC Synaptosome Proteomics Reveals Novel Pathways and Muscarinic Receptor Changes in a Learned Helplessness Mouse Model
Stressful events are a leading factor in development of depression. The medial prefrontal cortex (mPFC) is strongly associated with depression etiology and exposure to uncontrollable stressors results in synaptic dysfunction and loss. Learned helplessness is a behavioral paradigm that measures effec...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-20 | PXD073765 | Pride
Mpfc Acetylcholine Major depressive disorder Stress models Learned helplessness Muscarinic receptors Proteomics 
UnknownAgonist-selective activation of individual G-proteins by muscarinic receptors.
Not available
S-EPMC11053168 | biostudies-literature
UnknownNicotinic and muscarinic acetylcholine receptors shape ganglion cell response properties.
Not available
S-EPMC4294565 | biostudies-literature
UnknownMuscarinic receptors: from clinic to bench to clinic.
Not available
S-EPMC9486979 | biostudies-literature
UnknownNovel long-acting antagonists of muscarinic ACh receptors.
Not available
S-EPMC5913398 | biostudies-literature
UnknownFunctional Characterization of Muscarinic Receptors in Human Schwann Cells.
Not available
S-EPMC7555815 | biostudies-literature
UnknownSpontaneous Synaptic Activation of Muscarinic Receptors by Striatal Cholinergic Neuron Firing.
Not available
S-EPMC5234077 | biostudies-literature
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