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ProteomicsVHL synthetic lethality screens uncover CBF-β as a negative regulator of STING.
Clear cell renal cell carcinoma (ccRCC) represents the most common form of kidney cancer and is typified by biallelic inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene. Here, we undertake genome-wide CRISPR/Cas9 screening to reveal synthetic lethal interactors of VHL, and uncover th...
ORGANISM(S): Homo sapiens (Human) 
2026-02-13 | PXD074426 | Pride
Sting Cbf-β Vhl Clear cell renal cell carcinoma Type i interferon 
MetabolomicsMitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Somatic DNMT3A R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk1,2. Preventing expansion of DNMT3A-R882-mutant haematopoietic stem/progenitor cells (HSPCs) may therefore avert progression to AML. To ide...
2025-02-06 | MTBLS12201 | MetaboLights
ProteomicsProtein quality control by MARCH6/TRC8
Forward genetic screens in human cells we find that the proteasome-mediated degradation of the soluble misfolded reporter, mCherry-CL1, involves two ER-resident E3 ligases, MARCH6 and TRC8. To identify a more physiological correlate we used quantitative mass spectrometry and found that TRC8 and MARC...
ORGANISM(S): Homo sapiens (Human) 
2018-04-18 | PXD008955 | Pride
Erad March6 Intramembrane proteolysis Trc8 Protein quality control 
ProteomicsABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
2-oxoglutarate (2-OG or α-ketoglutarate) relates mitochondrial metabolism to cell function by modulating the activity of 2-OG dependent dioxygenases involved in the hypoxia response and DNA/histone modifications. However, metabolic pathways that regulate these oxygen and 2-OG sensitive enzymes remai...
ORGANISM(S): Homo sapiens (Human) 
2020-07-27 | PXD020128 | Pride
Α-ketoglutarate Lipid peroxidation 2-oxoglutarate dehydrogenase complex Lipoic acid Hypoxia inducible factor 2-oxoglutarate Abhd11 Lipoylation Α-ketoglutarate dehydrogenase complex 
MetabolomicsABHD11/ROLIP maintains the TCA cycle by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
2-oxoglutarate (2-OG) relates mitochondrial metabolism to cell function: conversion of 2-OG to succinyl-CoA by the 2-OG dehydrogenase complex (OGDHc) is rate-limiting for the Tricarboxylic Acid (TCA) cycle, but 2-OG is also required for oxygen sensitive enzymes (2-OG dependent dioxygenases) that hav...
2020-08-10 | MTBLS1875 | MetaboLights
ProteomicsFIH regulates cellular metabolism through hydroxylation of the deubiquitinase OTUB1.
The asparagine hydroxylase, factor inhibiting HIF (FIH) confers oxygen-dependence upon the hypoxia-inducible factor (HIF), a master regulator of the cellular adaptive response to hypoxia. Studies investigating whether asparagine hydroxylation is a general regulatory oxygen-dependent modification hav...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080695 | MassIVE
ProteomicsQuantitative proteomic analysis of SARS-CoV-2 infection of primary human airway ciliated cells and lung epithelial cells demonstrates the effectiveness of SARS-Cov-2 innate immune evasion
We used two model systems to characterise the changes caused by SARS-CoV-2 using quantitative proteomics. We used primary human epithelial cells differentiated at the air-liquid interface, first describing the relative abundance of proteins found in each major cell type of the epithelium, and then c...
ORGANISM(S): Homo sapiens (Human) 
2022-05-26 | PXD034135 | Pride
Sars-cov-2 Hbec 
UnknownVenom of the Red-Bellied Black Snake Pseudechis porphyriacus Shows Immunosuppressive Potential.
Not available
S-EPMC7693913 | biostudies-literature
UnknownDietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice.
Not available
S-EPMC12495292 | biostudies-literature
UnknownIncreased cognitive workload evokes greater neurovascular coupling responses in healthy young adults.
Not available
S-EPMC8133445 | biostudies-literature
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